| Project/Area Number |
26893054
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Masui Yuri 東京大学, 医学部附属病院, 助教 (80735811)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 全身性強皮症 / アディポカイン / アディポネクチン |
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| Outline of Final Research Achievements |
In this study, we investigated the role of adiponectin in dermal fibrotic process of systemic sclerosis(SSc) using skin samples from SSc and healthy control subjects and Adipo-/- mice applied with bleomycin-induced dermal fibrosis model.
In a series of studies using animal models, bleomycin-induced thickening of back skin was 1.5 times thicker in Adipo-/- mice than in wild type mice. In addition, the Col1a1 and Col1a2 mRNA levels and the number of myofibroblasts in lesional skin were significantly increased in Adipo-/- mice compared with wild type mice.
Of note, mRNA levels of AdipoRI and AdipoRII genes were significantly lower in SSc fibroblasts than in normal fibroblasts. Taken together, these results suggest that anti-fibrotic effect of adiponectin regulates the fibrotic process in vivo and the impaired response to adiponectin of SSc fibroblasts due to the decreased expression of its receptors potentially contributes to the development of skin sclerosis in SSc.
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