| Project/Area Number |
26893055
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Hosokawa Rei 東京大学, 医学部附属病院, 助教 (60463866)
|
|---|
| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 皮膚T細胞 / resident memory T細胞 / 皮膚免疫 / T細胞 / 皮膚居住T細胞 |
|---|
| Outline of Final Research Achievements |
Expression process of CD69 and CD103, which are known as skin-resident memory T cell markers, were investigated. When circulating T cells, which do not express CD69 or CD103, were co-cultured with keratinocyte sheets or fibroblast sheet, it turned out that T cells express CD69 and CD103 when co-cultured with keratinocytes (epidermal condition) and express CD69 when co-cultured with fibroblasts (dermal condition). Thus, it was assumed that T cells express CD69 when they enter into dermis and further express CD103 after entering into epidermis. In human T-cell trafficking mouse model, when circulating T cells were eliminated by alemtuzumab, CD69+CD103+ T cells and CD69+CD103- T cells were left intact in the grafted skin. This result indicates that these two fractions function as resident memory T cells in human skin.
|
