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Analysis on the possibility of various tissue regeneration with the Nanogel possesing a molecular chaperone function

Research Project

Project/Area Number 26893073
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Miyahara Takayuki  東京医科歯科大学, 歯学部附属病院, 医員 (30735246)

Research Collaborator KASUGAI Shohei  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70161049)
SHIOTA Makoto  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (90196353)
TACHIKAWA Noriko  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (70236537)
KURODA Shinji  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (50323689)
NAKATA Hidemi  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (30451967)
AKIYOSHI Kazunari  京都大学, 工学研究科高分子化学専攻, 教授 (90201285)
SHIMODA Asako  京都大学, 工学研究科高分子化学専攻 (90712042)
HASHIMOTO Yoshihide  東京医科歯科大学, 生体材料工学研究所生体機能修復研究部門, 物質医工学分野助教 (40638384)
Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords骨再生 / GBR / Nanogel / membrane / collagen / nano gel / 再生医療 / メンブレン / 軟組織再生 / 硬組織再生 / ドラッグデリバリーシステム(DDS) / ナノキャリアー / 分子シャペロン機能 / 骨組織再生 / 神経組織再生 / Guided Bone Regeneration / 国際情報交換
Outline of Final Research Achievements

The purposes of this study were to analyze the gene expression, radiography and histology of nanogel for (1) bone regeneration, (2) soft tissue regeneration, and (3) nerve tissue regeneration. (1) The radiological analysis as bone regeneration revealed that the amount of newly formed bone in both nanogel groups were higher than collagen group (there were significant differences). (2) Histological evaluation of the soft tissue regeneration revealed that the healing of soft tissue in nanogel membrane group was better than that in silicon membrane and collagen one. (3) Evaluation of nerve tissue regeneration will be conducted in our future study. Clinical application will be demanded.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (12 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Effects of a polysaccharide nanogel-crosslinked membraneon wound healing2016

    • Author(s)
      Hiroki Maeda,Hiroshi Kobayashi,Takayuki Miyahara,Yoshihide Hashimoto,Kazunari Akiyoshi,Shohei Kasugai
    • Journal Title

      Jouranal of Biomedical Materials research Part B Applied Materials

      Volume: 未定 Issue: 3 Pages: 554-560

    • DOI

      10.1002/jbm.b.33571

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lateral Bone Window Closing Technique with Poly-L-Lactic Acid (PLLA) Membrane in the Augmentation of the Maxillary Sinus without Grafting Material: Evaluation of Bone Healing in a Rabbit Model.2015

    • Author(s)
      Kusumoto Y, Tachikawa N, Munakata M, Miyahara T, Kasugai S.
    • Journal Title

      Clin Implant Dent Relat Res.

      Volume: - Issue: 2 Pages: 261-269

    • DOI

      10.1111/cid.12293

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of alpha tricalcium phosphate for vertical bone augmentation.2014

    • Author(s)
      Nyan M, Miyahara T, Noritake K, Hao J, Rodriguez R, Kasugai S.
    • Journal Title

      J Investig Clin Dent.

      Volume: 5(2) Issue: 2 Pages: 109-116

    • DOI

      10.1111/jicd.12022

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accelerated and enhanced bone formation on novel simvastatin-loaded porous titanium oxide surfaces.2014

    • Author(s)
      Nyan M, Hao J, Miyahara T, Noritake K, Rodriguez R, Kasugai S.
    • Journal Title

      Clin Implant Dent Relat Res.

      Volume: 16(5) Issue: 5 Pages: 675-683

    • DOI

      10.1111/cid.12045

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dental implant treatment in esthetic region2016

    • Author(s)
      T Miyahara
    • Organizer
      The 36th Myanmar Dental Conference and 17th FDI-MDA Joint Educational Meeting
    • Place of Presentation
      Yangon Myanmar
    • Year and Date
      2016-01-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Extraction Site Management with Apatite Fiber Material : Clinical study2015

    • Author(s)
      T Miyahara, M Fujii, J Hamaguchi, T Fujimori, M Shiota, S Kasugai
    • Organizer
      European Association for Osseointegration
    • Place of Presentation
      Stockholmsmässan Stockholm Sweden
    • Year and Date
      2015-09-24 – 2015-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Extraction Site Management with Apatite Fiber Material : Clinical study2015

    • Author(s)
      T Miyahara, M Fujii, J Hamaguchi, T Fujimori, M Shiota, S Kasugai
    • Organizer
      European Association for Osseointegration
    • Place of Presentation
      Stockholm Sweden
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exploitation of a novel polysaccharide nanogel cross-linking membrane for guided bone regeneration (GBR).2015

    • Author(s)
      T Miyahara
    • Organizer
      The Republic of the Union of Myanmar Ministry of Health Department of Medical Science University of Dental Medicine, Yangon
    • Place of Presentation
      The Republic of the Union of Myanmar Ministry of Health Department of Medical Science University of Dental Medicine, Yangon Myanmar
    • Year and Date
      2015-05-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 上顎臼歯部における傾斜埋入或いは非傾斜埋入インプラントの臨床的検討2014

    • Author(s)
      宮原 宇将,淵上 慧, 立川 敬子, 鶴見 和久, 春日井 昇平
    • Organizer
      日本顎顔面インプラント学会総会
    • Place of Presentation
      ビッグハート出雲 島根
    • Year and Date
      2014-11-29 – 2014-11-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Novel material consisted of apatite fiber for ridge preservation2014

    • Author(s)
      T Miyahara, M Fuji, T Fujimori, M Shiota, S Kasugai
    • Organizer
      European Association for Osseointegration
    • Place of Presentation
      Auditorium Parco Della Musica Roma Italy
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 上顎結節を利用した傾斜埋入インプラントの臨床的検討2014

    • Author(s)
      淵上 慧, 宮原 宇将,立川 敬子, 鶴見 和久, 春日井 昇平
    • Organizer
      日本口腔インプラント学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト抜歯窩に応用した吸収性ハイドロキシアパタイトファイバーの放射線学的ならびに組織学的検討2014

    • Author(s)
      藤井 政樹, 宮原 宇将, 塩田 真, 春日井 昇平
    • Organizer
      日本口腔インプラント学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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