The pathological role of brown adipose tissue dysfunction in age related disorders.

• Project/Area Number: 26893080
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Niigata University
• Principal Investigator: Shimizu Ippei 新潟大学, 医歯(薬)学総合研究科, 特任准教授 (60444056)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 褐色脂肪 / 心不全 / 肥満 / NASH / 褐色アディポカイン / 褐色脂肪由来代謝産物 / 心筋代謝リモデリング / 褐色脂肪不全

Outline of Final Research Achievements

Accumulating evidence indicates that brown adipose tissue (BAT) is the critical regulator for systemic metabolic dysfunction. Our results suggested that BAT dysfunction develops upon left ventricular pressure overload in a murine heart failure model, and causal for the progression of heart failure. BAT transplantation ameliorated cardiac dysfunction. We are currently examining to find a novel metabolites involved in disturbing cardiac metabolism with metabolome analyses. We also found that in dietary obese model, obesity associated pro-fibrotic protein (OAFP) is produced and secreted predominantly from BAT and promotes fibrosis in the liver. OAFP level in the serum was also increased in non alcoholic steatohepatitis (NASH) patients, and OAFP gain of function model promoted fibrosis in the liver. Further studies would elucidate the pathological role of OAFP in NASH.

Research Products

• [Presentation] The pathological roles of brown and white adipose tissue dysfunction in heart failure, obesity and diabetes (2016)
  • Author(s): 清水逸平
  • Organizer: 第80回日本循環器学会総会・学術集会
  • Place of Presentation: 仙台市民会館（宮城県、仙台市）
  • Year and Date: 2016-03-18
  • Invited
• [Presentation] 心不全、肥満における脂肪不全の意 (2015)
  • Author(s): 清水逸平
  • Organizer: 第38回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド（兵庫県、神戸市）
  • Year and Date: 2015-12-02
  • Invited
• [Presentation] 心不全における老化シグナルの意義 (2015)
  • Author(s): 清水逸平
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 愛媛県県民文化会館（愛媛県、松山市）
  • Year and Date: 2015-10-09
  • Invited
• [Presentation] 肥満と心血管老化 (2015)
  • Author(s): 清水逸平
  • Organizer: 第36回日本肥満学会
  • Place of Presentation: 名古屋国際会議場（愛知県、名古屋市）
  • Year and Date: 2015-10-02
  • Invited
• [Patent(Industrial Property Rights)] 非アルコール性脂肪性肝炎治療剤 (2015)
  • Inventor(s): 清水逸平、南野徹
  • Industrial Property Rights Holder: 国立大学法人新潟大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-10-13