| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We examined AQP expression by tissue microarray (TMA).In biliary tract cancer cell lines after the bile acid exposure showed a decreased expression of AQP-1 gene.AQP-1 was involved in the progress of cholestasis and cancer. AQP-1 were considered to be useful as a prognostic factor in biliary tract cancer.In biliary tract cancer patients who underwent chemotherapy, PTEN expression group, compared to a non-expression group had a good prognosis (DSS; p <0.01).Our result suggest that AQP and PTEN may contribute to the apoptosis and chemotherapy sensitivity.
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