The search for new anti-cancer drug therapy in biliary tract cancer (targeted to Aquaporin)
| Project/Area Number |
26893091
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | University of Toyama |
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Principal Investigator |
Sekine Shinichi 富山大学, 大学院医学薬学研究部(医学), 助教 (60649292)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 胆道癌 / アクアポリン / 化学療法 / トランスレーショナルリサーチ |
|---|
| Outline of Final Research Achievements |
We examined AQP expression by tissue microarray (TMA).In biliary tract cancer cell lines after the bile acid exposure showed a decreased expression of AQP-1 gene.AQP-1 was involved in the progress of cholestasis and cancer. AQP-1 were considered to be useful as a prognostic factor in biliary tract cancer.In biliary tract cancer patients who underwent chemotherapy, PTEN expression group, compared to a non-expression group had a good prognosis (DSS; p <0.01).Our result suggest that AQP and PTEN may contribute to the apoptosis and chemotherapy sensitivity.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] The Usefulness of Nutritional Index CONUT for Risk Assessment and Prognosis after Pancreaticoduodenectomy2016
Author(s)
Shinichi Sekine*, Takuya Nagata, Tomoyuki Okumura, Shunsuke Kawai, Katsuhisa Hirano, Takeshi Miwa, Makoto Moriyama, Hirofumi Kojima, Isaya Hashimoto, Kazuto Shibuya, Shozo Hojo, Isaku Yoshioka, Koshi Matsui, Shigeaki Sawada and Kazuhiro Tsukada
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Journal Title
International Journal of Cancer and Clinical Research
Volume: 3-1
Pages: 041-041
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 十二指腸乳頭部癌における膵頭十二指腸切除後の予後予測2015
Author(s)
関根慎一, 小島博文, 森山亮仁, 橋本伊佐也, 渋谷和人, 北條荘三, 吉岡伊作, 松井恒志, 奥村知之, 長田拓哉, 塚田一博
Organizer
第51回日本胆道学会学術集会
Place of Presentation
宇都宮
Year and Date
2015-09-17
Related Report
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[Presentation] 栄養指標CONUTは胆道癌における膵頭十二指腸切除術後の長期予後と関連する.2015
Author(s)
関根慎一,長田拓哉, 吉岡伊作, 渋谷和人, 松井恒志, 平野勝久, 渡辺徹, 森山亮仁, 橋本伊佐也, 北條荘三, 堀亮太, 奥村知之, 塚田一博
Organizer
第115回日本外科学会定期学術集会
Place of Presentation
名古屋
Year and Date
2015-04-16
Related Report
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