Mechanism elucidation and therapeutic development of sleep disorder induced by chronic pain

Research Project

Project/Area Number	26893092
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Anesthesiology
Research Institution	University of Toyama
Principal Investigator	ITO HISAKATSU 富山大学, 大学病院, 助教 (60736388)
Project Period (FY)	2014-08-29 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	慢性痛 / 睡眠 / 三環系抗うつ薬 / セロトニン / 痛み / 脳波 / 行動実験 / 神経科学
Outline of Final Research Achievements	We analyzed the electroencephalogram of neuropathic pain model mice and evaluated the effects of amitriptyline (Tricyclic antidepressants) and MDL 100907 (selective 5-HT2A receptor antagonist) on sleep their conditions. As a results, we found that amitriptyline and MDL 100907 improved the sleep disturbance induced by chronic pain.Our results suggest that amitriptyline improves secondary sleep disturbance to regulate the overactive of 5-HTergic neurons induced by chronic neuropathic pain.