• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of non-coding RNA in cancer initiation and cancer progression

Research Project

Project/Area Number 26893093
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionKanazawa University

Principal Investigator

Terashima Minoru  金沢大学, がん進展制御研究所, 助教 (80507434)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords癌 / エピジェネティクス / non-coding RNA / レトロウイルス挿入変異
Outline of Final Research Achievements

Many cancer-related genes were identified by retroviral insertional mutagenesis. We also found non-coding RNAs are targets of retroviral integration and are therefore involved in cancer. Among them, we focused on two non-coding RNAs, NEAT1 and JPX. Previous studies showed that NEAT1 can be involved in acute promyelocytic leukemia and JPX is involved in the regulation of X chromosome inactivation. In this study, we found that NEAT1 and JPX were downregulated in high grade breast cancer patients and were downregulated in hypoxia that can enhance tumor progression. These findings suggest that downregulated-NEAT1 and downregulated-JPX may be involved in breast cancer progression.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (13 results)

All 2016 2015 2014 Other

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Acknowledgement Compliant: 7 results,  Open Access: 6 results) Presentation (3 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.2016

    • Author(s)
      Ishimura A, Terashima M, Tange S and Suzuki T.
    • Journal Title

      Cell Tissue Res.

      Volume: 363 Issue: 3 Pages: 723-33

    • DOI

      10.1007/s00441-015-2276-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression.2015

    • Author(s)
      Terashima M, Barbour S, Ren J, Yu W, Han Y, Muegge K.
    • Journal Title

      Epigenetics

      Volume: 10 Issue: 9 Pages: 861-871

    • DOI

      10.1080/15592294.2015.1075691

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences.2015

    • Author(s)
      Ren J, Briones V, Barbour S, Yu W, Han Y, Terashima M, Muegge K.
    • Journal Title

      Nucleic Acids Res.

      Volume: 43 Issue: 3 Pages: 1444-1455

    • DOI

      10.1093/nar/gku1371

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity.2014

    • Author(s)
      Yu W, Briones V, Lister R, McIntosh C, Han Y, Lee EY, Ren J, Terashima M, Leighty RM, Ecker JR, Muegge K.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111 Issue: 16 Pages: 5890-5895

    • DOI

      10.1073/pnas.1320945111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways.2014

    • Author(s)
      Yu W, McIntosh C, Lister R, Zhu I, Han Y, Ren J, Landsman D, Lee E, Briones V, Terashima M, Leighty R, Ecker JR, Muegge K.
    • Journal Title

      Genome Res.

      Volume: 24 Issue: 10 Pages: 1613-1623

    • DOI

      10.1101/gr.172015.114

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-beta.2014

    • Author(s)
      Oktyabri D, Tange S, Terashima M, Ishimura A and Suzuki T.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 453 Issue: 1 Pages: 124-130

    • DOI

      10.1016/j.bbrc.2014.09.082

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] JARID2 is involved in Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines.2014

    • Author(s)
      Tange S, Oktyabri D, Terashima M, Ishimura A and Suzuki T.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 12 Pages: e115684-e115684

    • DOI

      10.1371/journal.pone.0115684

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] JARID2 is involved in TGF-beta-induced epithelial-mesenchymal-transition of cancer cells2015

    • Author(s)
      寺島 農, 丹下 正一朗, Dulamsuren Oktyabri, 石村 昭彦, 鈴木 健之
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 父親の高脂肪食摂取が自身の精子ヒストンおよび子に及ぼす影響2015

    • Author(s)
      寺島 農, Barbour Samantha, Ren Jianke, Yu Weishi, Han Yixing, Kathrin Muegge
    • Organizer
      第二回北陸エピジェネティクス研究会
    • Place of Presentation
      富山大学杉谷キャンパス
    • Year and Date
      2015-11-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Paternally transgenerational epigenetic effects on high-fat diet-induced obesity in mice2015

    • Author(s)
      Minoru Terashima, Weishi Yu, Jianke Ren, Yixing Han, Kathrin Muegge
    • Organizer
      日本癌学会シンポジウム/共同利用・共同研究拠点シンポジウム
    • Place of Presentation
      石川県立音楽堂交流ホール
    • Year and Date
      2015-01-21 – 2015-01-22
    • Related Report
      2014 Annual Research Report
  • [Book] Epigenetics and Dermatology2015

    • Author(s)
      Qianjin Lu, Christopher C. Chang, Bruce C. Richardson, Yu Liu, Jieyue Liao, Jeung-Hoon Lee, Bin Liu, Xin Sheng Wang, Hui-Min Chen, M. Eric Gershwin, Patrick S.C. Leung, Haijing Wu, Christian M. Hedrich, Alexander Lo, Melissa Serravallo, Yixing Han, Jianke Ren, Weishi Yu, Kathrin Muegge, Minoru Terashima, et al.
    • Total Pages
      520
    • Publisher
      Academic Press
    • Related Report
      2014 Annual Research Report
  • [Remarks] 金沢大学がん進展制御研究所 機能ゲノミクス分野

    • URL

      http://ganken.cri.kanazawa-u.ac.jp/Genomics/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 金沢大学がん進展制御研究所 機能ゲノミクス分野

    • URL

      http://www.kanazawa-u.ac.jp/~ganken/Genomics/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-09-09   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi