The role of non-coding RNA in cancer initiation and cancer progression
| Project/Area Number |
26893093
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 癌 / エピジェネティクス / non-coding RNA / レトロウイルス挿入変異 |
|---|
| Outline of Final Research Achievements |
Many cancer-related genes were identified by retroviral insertional mutagenesis. We also found non-coding RNAs are targets of retroviral integration and are therefore involved in cancer. Among them, we focused on two non-coding RNAs, NEAT1 and JPX. Previous studies showed that NEAT1 can be involved in acute promyelocytic leukemia and JPX is involved in the regulation of X chromosome inactivation. In this study, we found that NEAT1 and JPX were downregulated in high grade breast cancer patients and were downregulated in hypoxia that can enhance tumor progression. These findings suggest that downregulated-NEAT1 and downregulated-JPX may be involved in breast cancer progression.
|
Report
(3 results)
Research Products
(13 results)
-
-
-
-
[Journal Article] CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity.2014
Author(s)
Yu W, Briones V, Lister R, McIntosh C, Han Y, Lee EY, Ren J, Terashima M, Leighty RM, Ecker JR, Muegge K.
-
Journal Title
Proc Natl Acad Sci U S A.
Volume: 111
Issue: 16
Pages: 5890-5895
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways.2014
Author(s)
Yu W, McIntosh C, Lister R, Zhu I, Han Y, Ren J, Landsman D, Lee E, Briones V, Terashima M, Leighty R, Ecker JR, Muegge K.
-
Journal Title
Genome Res.
Volume: 24
Issue: 10
Pages: 1613-1623
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
[Book] Epigenetics and Dermatology2015
Author(s)
Qianjin Lu, Christopher C. Chang, Bruce C. Richardson, Yu Liu, Jieyue Liao, Jeung-Hoon Lee, Bin Liu, Xin Sheng Wang, Hui-Min Chen, M. Eric Gershwin, Patrick S.C. Leung, Haijing Wu, Christian M. Hedrich, Alexander Lo, Melissa Serravallo, Yixing Han, Jianke Ren, Weishi Yu, Kathrin Muegge, Minoru Terashima, et al.
Total Pages
520
Publisher
Academic Press
Related Report
-
-
