Developmental programmed cell death of central auditory system

Research Project

Project/Area Number	26893098
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	Kanazawa University
Principal Investigator	Hatano Miyako 金沢大学, 附属病院, 助教 (30557484)
Project Period (FY)	2014-08-29 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,561,176 (Direct Cost: ¥1,970,136、Indirect Cost: ¥591,040) Fiscal Year 2015: ¥1,131,176 (Direct Cost: ¥870,136、Indirect Cost: ¥261,040) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	先天性難聴 / 聴覚中枢 / 蝸牛 / 人工内耳 / 発達期 / 内耳毒性 / 脳・神経 / 神経発達 / 医療 / 解剖学 / 言語発達 / 神経発達期 / プログラム細胞死
Outline of Final Research Achievements	Congenital profound hearing loss model by antimicrobial drug amikacin which have ototoxicity have been used. Histologic examination about the hair cells and spiral ganglion neuron in cochlea was carried out in normal and the amikacin-treated animals. In amikacin-treated animals degeneration was significant both hair cells and spiral ganglion neurons in the basal turn of cochlea. The amikacin-treated congenital hearing loss model is suspected to be affected especially high frequency sound with frequency characteristics of cochlea.

Report

(4 results)