| Project/Area Number |
26893102
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Shinshu University |
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Principal Investigator |
KAWATE Hisaka 信州大学, 医学系研究科, 研究員 (20507503)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 病態医化学 |
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| Outline of Final Research Achievements |
Adrenomedullin (AM) is recognized as a multifunctional bioactive peptide. In this study, we analyzed AM-RAMP2 system in metabolic regulation. We found that high-fat diet induced enhanced obesity in heterozygous RAMP2 knockout mice. To clarify the pathophysiological roles of AM-RAMP2 system in adipose tissue, we generated adipocyte-specific RAMP2 knockout mice (A-RAMP2-/-). Even on normal diet, A-RAMP2-/- showed spontaneous obesity from 5 week-old with decreased oxygen and energy consumption. In A-RAMP2-/-, white adipose tissue (WAT) showed elevated expression of inflammatory cytokines and downregulation of β oxidation-related genes. On the other hand, brown adipose tissue (BAT) showed downregulation of mitochondria-related genes and elevation of oxidative stress.
From these results we concluded that AM-RAMP2 system directly regulates metabolism between WAT and BAT, and energy balance within the body.
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