| Project/Area Number |
26893103
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene and public health
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| Research Institution | Shinshu University |
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Principal Investigator |
MISAWA Yuka 信州大学, 医学部, 助教(受託研究) (10738644)
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| Research Collaborator |
NOMIYAMA Tetsuo 信州大学, 学術研究院医学系, 教授 (70286441)
INABA Yuji 信州大学, 学術研究院医学系, 准教授 (30334890)
TSUKAHARA Teruomi 信州大学, 学術研究院医学系, 講師 (50377652)
HIDAKA Yoshihiko 信州大学, 学術研究院医学系(医学部附属病院), 助教 (40624713)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 発達障害 / 周産期脳障害 / 周産期ストレス / バイオマーカー / サイトカイン |
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| Outline of Final Research Achievements |
The aim of this study was to clarify the association between perinatal minimal brain damages and their developments which were estimated by Modified Checklist for Autism in Toddlers (M-CHAT), motor and speech development at the age of 18 months. The perinatal minimal brain damages were evaluated by pNf-H, TIMP-1, MMP-9 and several inflammatory cytokines which were obtained from stored cord blood samples. In the “not-passed” group of M-CHAT, MMP-9/TIMP-1 and IL-17 levels were significantly higher than the “passed” group. TIMP-1 levels were significantly lower and IL-17 levels were higher in the delayed speech development group than the normal one. TIMP-1 is inhibitor of MMP-9 that is hindrance factor of blood brain barrier. These results showed that the social and speech development at the age of 18 months were influenced by the minimal injury of blood brain barrier and inflammation mediated by IL-17.
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