Development of positional isomer differentiation method of synthetic cannabinoids by GC/MS/MS
| Project/Area Number |
26893105
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Legal medicine
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
Kusano Maiko 名古屋大学, 医学(系)研究科(研究院), 特任助教 (60733574)
|
|---|
| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 分析化学 / 危険ドラッグ / 異性体識別法 / GC/MS/MS / 異性体識別方 |
|---|
| Outline of Final Research Achievements |
Synthetic cannabinoids (SC) have structural/positional isomers which may not all be regulated, thus isomeric differentiation becomes crucial as new designer drugs continuously emerge with minor modifications.
Positional isomer differentiation of the SCs JWH-081, JWH-122, JWH-210, and their isomers was attained by gas chromatography-tandem mass spectrometry (GC-MS/MS). Product ions with the same m/z are suspected to have different properties such as ion configuration and internal energy depending on the position of the functional group, producing characteristic spectra allowing for isomeric differentiation.
Furthermore, differentiation of the hydroxyindole metabolite isomers of JWH-018 was also attained. Results were applied as a hydroxyl-position determining method for the metabolites of JWH-018 by GC-MS/MS in MRM mode to JWH-018 administered mice. Hydroxylation at the 6-position was found to be the likely dominant pathway for JWH-018 metabolism to produce the hydroxyindole metabolites.
|
Report
(3 results)
Research Products
(13 results)
-
-
-
-
-
-
[Presentation] Development of a hydroxyl-position determining method for the metabolites of naphthoylindole-type synthetic cannabinoids by GC/MS/MS2015
Author(s)
Maiko Kusano, Kei Zaitsu, Mayumi Yamanaka, Kazuaki Hisatsune, Tomomi Asano, Kentaro Taki, Yumi Hayashi, Hitoshi Tsuchihashi, and Akira Ishii
Organizer
Society of Forensic Toxicologists 2015
Place of Presentation
Atlanta, GA, USA
Year and Date
2015-10-19
Related Report
Int'l Joint Research
-
[Presentation] Determination of newly encountered designer drugs α-PHP and acetylfentanyl in an acute intoxication case by LC/Q-TOFMS2015
Author(s)
Kazuaki Hisatsune, Kei Zaitsu, Maiko Kusano, Mayumi Yamanaka, Jun’ichi Nakajima, Takako Moriyasu, Atsushi Ishiba, Minemasa Hida, Hitoshi Tsuchihashi, Akira Ishii
Organizer
The 53rd Annual Meeting of the International Association of Forensic Toxicologists
Place of Presentation
Florence, Italy
Year and Date
2015-08-30
Related Report
Int'l Joint Research
-
-
-
-
-
-
[Presentation] Positional isomer differentiation of naphthoylindole-based synthetic cannabinoids by GC-MS/MS2014
Author(s)
M.Kusano, K. Zaitsu, H. Nakayama, J. Nakajima, M. Yamanaka, T. Moriyasu, S. Matsuta, M. Katagi, H. Tsuchihashi, and A. Ishii
Organizer
52nd Annual Meeting of the International Association of Forensic Toxicologists
Place of Presentation
Pan Americano Hotel (Buenos Aires, Argentina)
Year and Date
2014-11-09 – 2014-11-13
Related Report
