Research for autoantigens and autoantibodies in IgG4-related hypophysitis
| Project/Area Number |
26893106
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Nagoya University |
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Principal Investigator |
Iwama Shintaro 名古屋大学, 総合保健体育科学センター, 講師 (00733536)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 下垂体炎 / IgG4関連疾患 / IgG4関連下垂体炎 / 抗下垂体抗体 / 自己抗体 |
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| Outline of Final Research Achievements |
This study clarified that human pituitary glands were better than rat as substrate to find anti-pituitary antibodies. We also clarified the presence of specific autoantibodies against pituitary glands in IgG4-related hypophysitis (IgG4-RH). These findings lead to establish a novel biomaker for IgG4-RH.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis.2015
Author(s)
Iwama S, Sugimura Y, Kiyota A, Kato T, Enomoto A, Suzuki H, Iwata N, Takeuchi S, Nakashima K, Takagi H, Izumida H, Ochiai H, Fujisawa H, Suga H, Arima H, Shimoyama Y, Takahashi M, Nishioka H, Ishikawa SE, Shimatsu A, Caturegli P, Oiso Y.
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Journal Title
J Clin Endocrinol Metab.
Volume: 100
Issue: 7
Pages: E946-E954
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 尿崩症で発症した下垂体炎：臨床病理像、血中IgG4とRabphilin-3Aの相関2015
Author(s)
西岡 宏, 井下尚子, 椙村益久, 岩間信太郎, 鈴木尚宜, 竹下章, 福原紀章, 岡田満夫, 竹内靖博, 大磯ユタカ, 山田正三
Organizer
第19回日本内分泌病理学会 学術総会
Place of Presentation
佐賀
Year and Date
2015-10-24
Related Report
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[Presentation] Comparison of Human and Rat Pituitary Gland Substrates for the Detection of Serum Pituitary Antibodies in Patients with Biopsy-Proven Lymphocytic Hypophysitis2015
Author(s)
Shintaro Iwama, Naoko Iwata, Yoshihisa Sugimura, Kohtaro Nakashima, Seiji Takeuchi, Hiroshi Takagi, Hiroshi Arima, Teruhiko Koike, Yoshiharu Oshida, Patrizio Caturegli, and Yutaka Oiso
Organizer
ENDO 2015 (97th Annual Meeting of the Endocrine Society)
Place of Presentation
San Diego, USA
Year and Date
2015-03-07
Related Report
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