Research for autoantigens and autoantibodies in IgG4-related hypophysitis

• Project/Area Number: 26893106
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Endocrinology
• Research Institution: Nagoya University
• Principal Investigator: Iwama Shintaro 名古屋大学, 総合保健体育科学センター, 講師 (00733536)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 下垂体炎 / IgG4関連疾患 / IgG4関連下垂体炎 / 抗下垂体抗体 / 自己抗体

Outline of Final Research Achievements

This study clarified that human pituitary glands were better than rat as substrate to find anti-pituitary antibodies. We also clarified the presence of specific autoantibodies against pituitary glands in IgG4-related hypophysitis (IgG4-RH). These findings lead to establish a novel biomaker for IgG4-RH.

Research Products

• [Journal Article] Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis. (2015)
  • Author(s): Iwama S, Sugimura Y, Kiyota A, Kato T, Enomoto A, Suzuki H, Iwata N, Takeuchi S, Nakashima K, Takagi H, Izumida H, Ochiai H, Fujisawa H, Suga H, Arima H, Shimoyama Y, Takahashi M, Nishioka H, Ishikawa SE, Shimatsu A, Caturegli P, Oiso Y.
  • Journal Title: J Clin Endocrinol Metab. Volume: 100 Issue: 7 Pages: E946-E954
  • DOI: 10.1210/jc.2014-4209
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] リンパ球性漏斗下垂体後葉炎の自己抗原ラブフィリン3Aの同定 (2015)
  • Author(s): 岩間信太郎、椙村益久
  • Journal Title: 日本内分泌学会雑誌 JES News Volume: 91 Pages: 157-157
• [Journal Article] 自己免疫性下垂体炎の自己抗原の同定と新規診断マーカー開発への挑戦 (2015)
  • Author(s): 岩間信太郎
  • Journal Title: 総合保健体育科学 Volume: 38 Pages: 27-27
• [Journal Article] 下垂体炎の新規自己抗体の同定と臨床応用への挑戦 (2015)
  • Author(s): 岩間信太郎
  • Journal Title: 最新医学 Volume: 70 Pages: 967970-967970
• [Journal Article] 抗下垂体抗体の評価法とその臨床的意義 (2014)
  • Author(s): 岩間信太郎、椙村益久、押田芳治、大磯ユタカ
  • Journal Title: 内分泌・糖尿病・代謝科 Volume: 39 Pages: 69-75
  • NAID: 40020175906
• [Presentation] 尿崩症で発症した下垂体炎：臨床病理像、血中IgG4とRabphilin-3Aの相関 (2015)
  • Author(s): 西岡 宏, 井下尚子, 椙村益久, 岩間信太郎, 鈴木尚宜, 竹下章, 福原紀章, 岡田満夫, 竹内靖博, 大磯ユタカ, 山田正三
  • Organizer: 第19回日本内分泌病理学会 学術総会
  • Place of Presentation: 佐賀
  • Year and Date: 2015-10-24
• [Presentation] ヒトまたはラット下垂体切片を用いた抗下垂体抗体測定法の有用性に関する検討 (2015)
  • Author(s): 岩田尚子、岩間信太郎、椙村益久、中島孝太郎、竹内誠治、泉田久和、藤沢治樹、高木博史、有馬寛、大磯ユタカ
  • Organizer: 第88回 日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-29
• [Presentation] イピリムマブによる二次性下垂体炎患者における抗下垂体抗体の解析 (2015)
  • Author(s): 岩間信太郎、Alessandra De Remigis、Patrizio Caturegli、椙村益久、大磯ユタカ
  • Organizer: 第88回 日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-28
• [Presentation] Comparison of Human and Rat Pituitary Gland Substrates for the Detection of Serum Pituitary Antibodies in Patients with Biopsy-Proven Lymphocytic Hypophysitis (2015)
  • Author(s): Shintaro Iwama, Naoko Iwata, Yoshihisa Sugimura, Kohtaro Nakashima, Seiji Takeuchi, Hiroshi Takagi, Hiroshi Arima, Teruhiko Koike, Yoshiharu Oshida, Patrizio Caturegli, and Yutaka Oiso
  • Organizer: ENDO 2015 (97th Annual Meeting of the Endocrine Society)
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-03-07
• [Book] New専門医を目指すケース・メソッド・アプローチ 内分泌疾患 第3版 (2016)
  • Author(s): 岩間信太郎、椙村益久
  • Total Pages: 11
  • Publisher: 日本医事新報社
• [Remarks] 名古屋大学教員データベース
  • URL: http://profs.provost.nagoya-u.ac.jp/view/html/100007854_ja.html