Analysis of rare copy number variations in schizophrenia
Project/Area Number |
26893108
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Psychiatric science
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Research Institution | Nagoya University |
Principal Investigator |
KUSHIMA Itaru 名古屋大学, 高等研究院(医), 特任助教 (00732645)
|
Project Period (FY) |
2014-08-29 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | CNV / 統合失調症 / ゲノムコピー数変異 / シナプス |
Outline of Final Research Achievements |
Rare copy number variations (CNVs) are known to be involved in risk for schizophrenia (SCZ). Phenotypes of patients with 4 SCZ-associated CNVs were examined in detail, and high rate of comorbidity of neurodevelopmental disorders and/or congenital diseases was observed. In trio analysis, deletions at 3q29 and 22q11.21 were found to be de novo, providing additional evidence for their clinical significance. In bioinformatics analysis of CNV data, synaptic dysfunction was identified as an underlying mechanism for SCZ.
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Report
(2 results)
Research Products
(5 results)
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[Journal Article] Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility2015
Author(s)
Kimura, H. Tsuboi, D. Wang, C. Kushima, I. Koide, T. Ikeda, M. Iwayama, Y. Toyota, T. Yamamoto, N. Kunimoto, S. Nakamura, Y. Yoshimi, A. Banno, M. Xing, J. Takasaki, Y. Yoshida, M. Aleksic, B. Uno, Y. Okada, T. Iidaka, T. Inada, T. Suzuki, M. Ujike, H. Kunugi, H. Kato, T. Yoshikawa, T. Iwata, N. Kaibuchi, K. Ozaki, N.
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Journal Title
Schizophrenia bulletin
Volume: 印刷中
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Replication of enhanced carbonyl stress in a subpopulation of schizophrenia2014
Author(s)
Miyashita M, Arai M, Yuzawa H, Niizato K, Oshima K, Kushima I, Hashimoto R, Fukumoto M, Koike S, Toyota T, Ujike H, Arinami T, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Miyata T, Itokawa M
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Journal Title
Psychiatry Clin Neurosci
Volume: 68
Issue: 1
Pages: 83-84
DOI
Related Report
Peer Reviewed
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[Journal Article] Resequencing and Association Analysis of PTPRA, a Possible Susceptibility Gene for Schizophrenia and Autism Spectrum Disorders2014
Author(s)
Xing J, Wang C, Kimura H, Takasaki Y, Kunimoto S, Yoshimi A, Nakamura Y, Koide T, Banno M, Kushima I, Uno Y, Okada T, Aleksic B, Ikeda M, Iwata N, Ozaki N.
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Journal Title
PLoS One
Volume: 9
Issue: 1-3
Pages: 149-156
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Resequencing and association analysis of PTPRA, a possible susceptibility gene for schizophrenia and autism spectrum disorders2014
Author(s)
Xing J, Wang C, Kimura H, Takasaki Y, Kunimoto S, Yoshimi A, Nakamura Y, Koide T, Banno M, Kushima I, Uno Y, Okada T, Aleksic B, Ikeda M, Iwata N, Ozaki N
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Journal Title
PLoS One
Volume: 9(11)
Issue: 11
Pages: e112531-e112531
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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