Molecular based analysis of HSP47 and novel therapies development in intestinal fibrosis of Crohn`s disease
| Project/Area Number |
26893122
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
HONZAWA Yusuke 京都大学, 医学(系)研究科(研究院), 医員 (90737884)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | クローン病 / 炎症性腸疾患 / heat shock protein 47 / 腸管線維化 |
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| Outline of Final Research Achievements |
To elucidate the mechanisms of intestinal fibrosis related to Crohn`s disease (CD), we focused heat shock protein (HSP) 47 associated with several fibrotic disease in human and mouse intestinal tissues samples and cell lines. Expressions of HSP47, collagen, IL-17A were elevated in intestinal tissues of patients with CD. Additionally, IL-17A enhanced HSP47 and collagen production in human myofibroblast cell line (CCD-18Co) and mouse fibroblast cell line (NIH3T3). IL-17A-induced HSP47 expression associated with JNK pathway in these cell lines. These results suggested that the mechanisms of IL-17A-induced HSP47 contributed to the pathology of intestinal fibrosis of CD.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Ischemic enteritis with intestinal stenosis2016
Author(s)
Yorimitsu Koshikawa, Hiroshi Nakase, Minoru Matsuura, Takuya Yoshino, Yusuke Honzawa, Naoki Minami, Satoshi Yamada, Yumiko Yasuhara, Shigehiko Fujii, Toshihiro Kusaka, Dai Manaka, Hiroyuki Kokuryu
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Journal Title
Intestinal reserch
Volume: 14
Issue: 1
Pages: 89-95
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Osteopontin Deficiency Accelerates Spontaneous Colitis in Mice with Disrupted Gut Microbiota and Macrophage Phagocytic Activity2015
Author(s)
Takahiko Toyonaga, Hiroshi Nakase, Satoru Ueno, Minoru Matsuura, Takuya Yoshino, Yusuke Honzawa, Ayako Itou, Kazuyoshi Namba, Naoki Minami, Satoshi Yamada, Yorimitsu Koshikawa, Toshimitsu Uede, Tsutomu Chiba, Kazuichi Okazaki
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Journal Title
PloS One
Volume: 14
Issue: 8
Pages: e0135552-e0135552
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Involvement of interleukin-17A-induced expression of heat shock protein 47 in intestinal fibrosis in Crohn's disease2014
Author(s)
Honzawa Y, Nakase H, Shiokawa M, Yoshino T, Imaeda H, Matsuura M, Kodama Y, Ikeuchi H, Andoh A, Sakai Y, Nagata K, Chiba T
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Journal Title
Gut
Volume: 63
Issue: 12
Pages: 1902-12
DOI
Related Report
Peer Reviewed
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