| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
To elucidate the mechanisms of intestinal fibrosis related to Crohn`s disease (CD), we focused heat shock protein (HSP) 47 associated with several fibrotic disease in human and mouse intestinal tissues samples and cell lines. Expressions of HSP47, collagen, IL-17A were elevated in intestinal tissues of patients with CD. Additionally, IL-17A enhanced HSP47 and collagen production in human myofibroblast cell line (CCD-18Co) and mouse fibroblast cell line (NIH3T3). IL-17A-induced HSP47 expression associated with JNK pathway in these cell lines. These results suggested that the mechanisms of IL-17A-induced HSP47 contributed to the pathology of intestinal fibrosis of CD.
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