Pathogenicity and antigen of IgG4 antibody in patients with IgG4 related disease
Project/Area Number |
26893123
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Gastroenterology
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Research Institution | Kyoto University |
Principal Investigator |
Shiokawa Masahiro 京都大学, 医学(系)研究科(研究院), 医員 (50737880)
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Project Period (FY) |
2014-08-29 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | IgG4 / 自己免疫性膵炎 / IgG4関連疾患 / IgG4 / 抗原 / 病原性 / IgG4関連疾患 |
Outline of Final Research Achievements |
Objective: The pathogenic roles of IgGs, including IgG4, in patients with IgG4-RD remain unknown. Design: We examined the pathogenic activity of circulating IgGs in patients with IgG4-RD by injecting their IgGs into neonatal Balb/c mice. Binding of patients’ IgGs to pancreatic tissues was also analyzed in an ex vivo mouse organ culture model and in tissue samples of patients with autoimmune pancreatitis (AIP). Results: Subcutaneous injection of patients’ IgG, but not control IgG, induced pancreatic and salivary gland injuries. Pancreatic injury was also induced by injecting patients’ IgG1 or IgG4, with more destructive change induced by IgG1 than by IgG4. The potent pathogenic activity of patients’ IgG1 was significantly inhibited by simultaneous injection of patients’IgG4. Conclusions: IgG1 and IgG4 from patients with IgG4-RD have pathogenic activities through binding to affected tissues in neonatal mice.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Pathogenicity of Immunoglobulin G in Patients with IgG4-related Disease.2016
Author(s)
Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, Ueda T, Tsuda M, Yamauchi Y, Minami R, Sakuma Y, Ota Y, Maruno T, Kurita A, Sawai Y, Tsuji Y, Uza N, Matsumura K, Watanabe T, Notohara K, Tsuruyama T, Seno H, Chiba T.
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Journal Title
Gut
Volume: 未定
Issue: 8
Pages: 3292-3301
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Pathogenic Role of IgG in Patients with IgG4-related Disease on Neonatal Mice2016
Author(s)
Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, Ueda T, Tsuda M, Yamauchi Y, Minami R, Sakuma Y, Ota Y, Maruno T, Kurita A, Sawai Y, Tsuji Y, Uza N, Matsumura K, Watanabe T, Notohara K, Tsuruyama T, Seno H, Chiba T.
Organizer
DDW
Place of Presentation
San Diego
Year and Date
2016-05-21
Related Report
Int'l Joint Research
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[Book] 膵臓2015
Author(s)
塩川雅広
Total Pages
6
Publisher
日本膵臓学会
Related Report
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