| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Proliferative capacity of adult mammalian cardiomyocytes is very limited. However, its regulatory mechanism is still unclear. Since the recent studies have suggested that the cardiomyocytes soon after birth retain the proliferative capacity to repair damaged cardiac tissue in vivo, we searched possible regulatory factors of cardiomyocyte proliferation among the genes expressed dominantly in perinatal mouse heart and identified several genes that are expressed dominantly in the perinatal stage and also promote proliferation in H9C2 cells by using immunohistochemistry of mouse heart tissue, gene knockdown and overexpression in vitro. Next we investigate the molecular mechanism by which these genes regulate proliferation of the cells including cardiomyocytes.
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