Integrated analysis of clonal evolution at early stage of myelodysplastic syndrome.
| Project/Area Number |
26893127
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| Research Category |
Grant-in-Aid for Research Activity start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
Nagata Yasunobu 京都大学, 医学(系)研究科(研究院), 助教 (90739575)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 骨髄異形成症候群 / 全エクソンシークエンス / 再生不良性貧血 / ゲノム / 癌 |
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| Outline of Final Research Achievements |
We performed whole exome sequencing of 22 patients who diagnosed aplastic anemia and progressed myelodysplatic syndromes, which identified 66 mutations. They included not only PIGA which was already reported in aplastic anemia but also BCOR and BCORL1 which were not. Given analysis of different time points of several years from diagnosis, a tiny clone with mutations increased and acquired novel genetic alterations such as SETBP1 mutations, which related to advanced disease. In conclusion, variation of complicated clone structure informs the evolution from aplastic anemia to myelodysplatic syndrome.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.2016
Author(s)
Wakita S, Yamaguchi H, Ueki T, Usuki K, Kurosawa S, Kobayashi Y, Kawata E, Tajika K, Gomi S, Koizumi M, Fujiwara Y, Yui S, Fukunaga K, Ryotokuji T, Hirakawa T, Arai K, Kitano T, Kosaka F, Tamai H, Nakayama K, Fukuda T, Inokuchi K
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Journal Title
Blood
Volume: 60
Pages: 2491-2501
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Variegated RHOA mutations in adult T-cell leukemia/lymphoma.2016
Author(s)
Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, (9名), Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, Ogawa S
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Journal Title
Blood.
Volume: 127
Pages: 596-604
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] First-line treatment for severe aplastic anemia in children: bone marrow transplantation from a matched family donor versus immunosuppressive therapy.2015
Author(s)
Huang D, Nagata Y, Grossmann V, Radivoyevitch T, Yoshida K, Sekeres MA, Oakley K, Nguyen N, Shiraishi Y, Shiozawa Y, Chiba K, Tanaka H, Koeffler HP, Klein HU, Dugas M, Aburatani H, Miyano S, Haferlach C, Kern W, Haferlach T, Du Y, Ogawa S, Makishima H.
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Journal Title
Haematologica
Volume: 100(8)
Pages: 1784-1791
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.2015
Author(s)
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S.
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Journal Title
New England Journal of Medicine
Volume: 373
Pages: 35-35
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Integrated molecular analysis of adult T-cell leukemia/lymphoma.2015
Author(s)
Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, et al.
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Journal Title
Nat Genet
Volume: 47(11)
Pages: 1304-1315
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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