| Project/Area Number |
26893140
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 抗菌性 / 薬剤徐放 / ポリマー / 根管充填用材料 / オンデマンド |
|---|
| Outline of Final Research Achievements |
In this study, novel polyHEMA/TMPT particles loaded with cetylpyridinium chloride (CPC) were fabricated and incorporated into a HEMA-based endodontic sealer. Release profiles of CPC, antibacterial activities, physical properties, and sealing abilities of experimental sealers containing CPC-laoded hydrogel particles were evaluated in vitro. The experimental sealers containing CPC-loaded hydrogel particles demonstrated on-demand release of CPC. By the antibacterial activity tests using an infected dentin model, sealers containing CPC-loaded hydrogel particles were found to be effective to kill bacteria in dentinal tubules. In addition, it was confirmed that acceptable physical properties and sealing abilities could be obtained by adjusting the diameter of particles incorporated.
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