| Project/Area Number |
26893142
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hokkaido University (2015)
Osaka University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 象牙質 / コラーゲン / Cross-linker / 歯科材料 / 接着 / 劣化抑制 / 劣化 / 酵素 / 透過型電子顕微鏡観察 |
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| Outline of Final Research Achievements |
This study was aimed to acquire the long-term durability for resin-dentin bonding using cross-linker. We evaluated the ability of cross-linker to resist the degradation of dentin collagen caused by MMPs using immunostaining and the effect of cross-linker on the long-term durability of resin-dentin bonding with micro tensile testing, SEM and TEM observation.
The results of the immunostaining was not clear. We couldn't find the significant difference. We need to consider the concentration and application time of MMPs. For micro tensile bond strength, the strength of the cross-linker(riboflavin) applicated group was higher than that of other groups. Furthermore, the morphological observation by SEM showed that the excellent interface in all groups and the resin tags of cross-linker group were shorter than control but the density of them were almost the same between groups. We need to observe the interaction between bond strength and the morphology of the interface application time.
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