| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this study, trophic factors released by mesenchymal stem cells were examined for their paracrine effect on human periodontal tissue-forming cells.
Adipose tissue-derived mesenchymal stem cell (ADSC) conditioned medium stimulates the differentiation of human periodontal ligament cell (HPDL) to mineralized tissue-forming cells. Besides, ADSC secreted insulin-like growth factor binding protein 6 (IGFBP6). Furthermore, the positive effects of ADSC conditioned medium on HPDL differentiation were significantly suppressed by transfecting ADSCs with IGFBP6 siRNA. These results revealed the mechanism that ADSC transplanted into the periodontal tissue release trophic factors that can stimulate the differentiation of HPDLs to mineralized tissue-forming cells.
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