Analysis of the regulatory mechanism of FGF-2 by periodontal ligament specific molecule, PLAP-1
| Project/Area Number |
26893146
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯周再生医学 / 歯周病 / 歯周組織再生療法 / 歯根膜 / PLAP-1 / FGF-2 / 歯学 / ノックアウトマウス |
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| Outline of Final Research Achievements |
PLAP-1 is an extracellular matrix protein that is predominantly expressed in the periodontal ligament within periodontal tissue. It was previously revealed that PLAP-1 negatively regulates BMP-2 and TGF-β activity through direct interactions. However, the interaction between PLAP-1 and FGF-2, which is a critical growth factor in tissue homeostasis and repair, has not been defined yet. In this analysis,we revealed that PLAP-1 positively regulates FGF-2 activity. Topical application of recombinant FGF-2 in intrabony defects significantly stimulates periodontal regeneration. This approach may be useful in several regenerative medicine applications using extracellular matrixs and growth factors concomitantly.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] PLAP-1/asporin positively regulates FGF-2 activity2015
Author(s)
T Awata, S Yamada, K Tsushima, H Sakashita, S Yamaba, T Kajikawa, M Yamashita, M Takedachi, M Yanagita, M Kitamura, S Murakami.
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Journal Title
J Dent Res
Volume: 94
Issue: 10
Pages: 1417-24
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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