| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
PLAP-1 is an extracellular matrix protein that is predominantly expressed in the periodontal ligament within periodontal tissue. It was previously revealed that PLAP-1 negatively regulates BMP-2 and TGF-β activity through direct interactions. However, the interaction between PLAP-1 and FGF-2, which is a critical growth factor in tissue homeostasis and repair, has not been defined yet. In this analysis,we revealed that PLAP-1 positively regulates FGF-2 activity. Topical application of recombinant FGF-2 in intrabony defects significantly stimulates periodontal regeneration. This approach may be useful in several regenerative medicine applications using extracellular matrixs and growth factors concomitantly.
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