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Evaluation of angiogenesis and bone regeneration in osteonecrosis using bone marrow mononuclear cells transfected by microRNAs.

Research Project

Project/Area Number 26893163
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionHiroshima University

Principal Investigator

SHOJI TAKESHI  広島大学, 病院(医), 病院助教 (50736569)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords大腿骨頭壊死症 / microRNA / エクソソーム / 骨髄単核球 / 血管再生 / 血管新生
Outline of Final Research Achievements

The comprehensive analysis of miRNA and mRNA expression were performed using the femoral head that was obtained from the patient with osteonecrosis of femoral head. I evaluated the ability of osteogenic proliferation and vascularization using miRNA candidates, and lined up four candidates that ware considered to be useful for angiogenesis and bone regeneration. I also revealed that microRNA can be transfected into cells in other cultured cells such as myoblasts with exosomes that contained synthetic miRNA that was obtained from microRNA transfected mesenchymal stem cells, and microRNA increased density-dependently.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (2 results)

All 2015

All Presentation (2 results)

  • [Presentation] 大腿骨頭壊死症に対する骨頭回転骨切り術の成績2015

    • Author(s)
      庄司 剛士
    • Organizer
      第42回日本股関節学会学術集会
    • Place of Presentation
      グランフロント大阪(大阪市北区)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大腿骨頭壊死症に対する骨髄移植術2015

    • Author(s)
      庄司 剛士
    • Organizer
      第88回日本整形外科学会学術集総会
    • Place of Presentation
      神戸ポートピアホテル(神戸市中央区)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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