| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
After β6 protein monomers translation, it was believed to be degraded by the proteasome in the cytoplasm.However, β6 is by forming an αv and dimer, is not subject to degradation by the ubiquitin / proteasome system, was estimated to be stable expression.
Expression of integrin αvβ6, cell proliferation on any extracellular matrix proteins was not affected.However, cell migration capacity was reduced on extracellular matrix proteins other than laminin.When examined the effect on proteolytic activity of the integrin αvβ6, the MMP-9 activity on all of the extracellular matrix proteins was reduced. However, urokinase activity was not affected.Results of investigation of effect on tumorigenicity, the volume of the tumor formed in nude mice was suppressed by the expression of the integrin αvβ6.
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