Mechanisms of chronic itch via astrocytic STAT3 in the spinal cord

• Project/Area Number: 26893182
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pain science
• Research Institution: Kyushu University
• Principal Investigator: Shiratori-Hayashi Miho 九州大学, 薬学研究科(研究院), 研究員 (20735641)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 痒み / 慢性的な痒み / アトピー性皮膚炎 / 脊髄 / アストロサイト / 痒み過敏 / 慢性掻痒 / グリア細胞

Outline of Final Research Achievements

Using models of chronic itch such as atopic or contact dermatitis model mice, we identified LCN2 as an astrocytic STAT3-dependent upregulated factor that plays important roles in maintenance of chronic itch in the spinal dorsal horn. We also demonstrated that LCN2 participates in spinal itch sensitization through enhancement of itch-specific GRP-GRPR signaling in the dorsal horn.

Research Products

• [Journal Article] 脊髄後角におけるSTAT3依存的なアストロサイト活性化は痒みの慢性化に必要である (2016)
  • Author(s): 白鳥美穂・津田誠
  • Journal Title: 実験医学 Volume: 34 Pages: 87-90
• [Journal Article] STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch (2015)
  • Author(s): Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M
  • Journal Title: Nat Med Volume: 21 Issue: 8 Pages: 927-931
  • DOI: 10.1038/nm.3912
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 転写因子STAT3に依存的な脊髄後角におけるアストロサイトの活性化は慢性的なかゆみにおいて重要な役割をはたす (2015)
  • Author(s): 白鳥美穂・津田誠
  • Journal Title: First Author's Volume: 2015.8.13 Pages: 98
  • DOI: 10.7875/first.author.2015.098
  • Open Access
• [Presentation] 脊髄後角におけるSTAT3依存的なアストロサイト活性化は痒みの慢性化に関与する (2016)
  • Author(s): 白鳥美穂, 古賀啓祐, 齊藤秀俊, 高露雄太, 蜂須賀淳一, 岡野栄之, 古江増隆, 井上和秀, 津田誠
  • Organizer: 日本薬学会 第136年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-26
• [Presentation] 慢性掻痒におけるSTAT3依存的な活性化アストロサイトの関与 (2015)
  • Author(s): 白鳥美穂
  • Organizer: 第6回福岡薬理・生理学研究会
  • Place of Presentation: 福岡
  • Year and Date: 2015-12-24
• [Presentation] 慢性掻痒における脊髄後角アストロサイトSTAT3の関与 (2015)
  • Author(s): 白鳥美穂, 古賀啓祐, 齊藤秀俊, 高露雄太, 蜂須賀淳一, 岡野栄之, 古江増隆, 井上和秀, 津田誠
  • Organizer: 痛み研究会2015
  • Place of Presentation: 岡崎
  • Year and Date: 2015-12-17
• [Presentation] STAT3-dependent reactive astrocytes in the spinal dorsal horn contribute to the maintenance of chronic itch in mice. (2015)
  • Author(s): Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Junichi Hachisuka, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda
  • Organizer: Neuroscience 2015
  • Place of Presentation: Chicago
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Astrocytic lipocalin-2 in the spinal dorsal horn is required for chronic itch (2015)
  • Author(s): Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Junichi Hachisuka, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda
  • Organizer: 8th World Congress on Itch
  • Place of Presentation: Nara
  • Year and Date: 2015-09-27
  • Int'l Joint Research
• [Presentation] アトピー性皮膚炎モデルマウスの慢性的な痒みにおける脊髄後角アストロサイトの関与 (2015)
  • Author(s): 津田誠, 白鳥美穂
  • Organizer: 第45回日本精神神経薬理学会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] Essential role for STAT3-dependent reactive astrocytes in maintenance of chronic itch. (2015)
  • Author(s): Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Junichi Hachisuka, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda
  • Organizer: 第58回日本神経化学会大会
  • Place of Presentation: 大宮
  • Year and Date: 2015-09-11
• [Presentation] Role of STAT3-dependent reactive astrocytes in the spinal dorsal horn in chronic itch. (2015)
  • Author(s): Miho Shiratori-Hayashi, Kazuhide Inoue, Makoto Tsuda
  • Organizer: XII European Meeting on Glial Cells in Health and Disease
  • Place of Presentation: Bilbao
  • Year and Date: 2015-07-15
  • Int'l Joint Research
• [Remarks] [速報] Nature Medicine誌に論文が掲載 アトピー性皮膚炎に伴う慢性的な痒み
  • URL: http://www.phar.kyushu-u.ac.jp/bbs/view2.php?S_Publ_Year=2015&word=&page=1&B_Code=277