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Mechanisms of chronic itch via astrocytic STAT3 in the spinal cord

Research Project

Project/Area Number 26893182
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Pain science
Research InstitutionKyushu University

Principal Investigator

Shiratori-Hayashi Miho  九州大学, 薬学研究科(研究院), 研究員 (20735641)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords痒み / 慢性的な痒み / アトピー性皮膚炎 / 脊髄 / アストロサイト / 痒み過敏 / 慢性掻痒 / グリア細胞
Outline of Final Research Achievements

Using models of chronic itch such as atopic or contact dermatitis model mice, we identified LCN2 as an astrocytic STAT3-dependent upregulated factor that plays important roles in maintenance of chronic itch in the spinal dorsal horn. We also demonstrated that LCN2 participates in spinal itch sensitization through enhancement of itch-specific GRP-GRPR signaling in the dorsal horn.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (12 results)

All 2016 2015 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results) Remarks (1 results)

  • [Journal Article] 脊髄後角におけるSTAT3依存的なアストロサイト活性化は痒みの慢性化に必要である2016

    • Author(s)
      白鳥美穂・津田誠
    • Journal Title

      実験医学

      Volume: 34 Pages: 87-90

    • Related Report
      2015 Annual Research Report
  • [Journal Article] STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch2015

    • Author(s)
      Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M
    • Journal Title

      Nat Med

      Volume: 21 Issue: 8 Pages: 927-931

    • DOI

      10.1038/nm.3912

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 転写因子STAT3に依存的な脊髄後角におけるアストロサイトの活性化は慢性的なかゆみにおいて重要な役割をはたす2015

    • Author(s)
      白鳥美穂・津田誠
    • Journal Title

      First Author's

      Volume: 2015.8.13 Pages: 98

    • DOI

      10.7875/first.author.2015.098

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Presentation] 脊髄後角におけるSTAT3依存的なアストロサイト活性化は痒みの慢性化に関与する2016

    • Author(s)
      白鳥美穂, 古賀啓祐, 齊藤秀俊, 高露雄太, 蜂須賀淳一, 岡野栄之, 古江増隆, 井上和秀, 津田誠
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慢性掻痒におけるSTAT3依存的な活性化アストロサイトの関与2015

    • Author(s)
      白鳥美穂
    • Organizer
      第6回福岡薬理・生理学研究会
    • Place of Presentation
      福岡
    • Year and Date
      2015-12-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慢性掻痒における脊髄後角アストロサイトSTAT3の関与2015

    • Author(s)
      白鳥美穂, 古賀啓祐, 齊藤秀俊, 高露雄太, 蜂須賀淳一, 岡野栄之, 古江増隆, 井上和秀, 津田誠
    • Organizer
      痛み研究会2015
    • Place of Presentation
      岡崎
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] STAT3-dependent reactive astrocytes in the spinal dorsal horn contribute to the maintenance of chronic itch in mice.2015

    • Author(s)
      Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Junichi Hachisuka, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Astrocytic lipocalin-2 in the spinal dorsal horn is required for chronic itch2015

    • Author(s)
      Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Junichi Hachisuka, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda
    • Organizer
      8th World Congress on Itch
    • Place of Presentation
      Nara
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アトピー性皮膚炎モデルマウスの慢性的な痒みにおける脊髄後角アストロサイトの関与2015

    • Author(s)
      津田誠, 白鳥美穂
    • Organizer
      第45回日本精神神経薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Essential role for STAT3-dependent reactive astrocytes in maintenance of chronic itch.2015

    • Author(s)
      Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Junichi Hachisuka, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      大宮
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of STAT3-dependent reactive astrocytes in the spinal dorsal horn in chronic itch.2015

    • Author(s)
      Miho Shiratori-Hayashi, Kazuhide Inoue, Makoto Tsuda
    • Organizer
      XII European Meeting on Glial Cells in Health and Disease
    • Place of Presentation
      Bilbao
    • Year and Date
      2015-07-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Remarks] [速報] Nature Medicine誌に論文が掲載 アトピー性皮膚炎に伴う慢性的な痒み

    • URL

      http://www.phar.kyushu-u.ac.jp/bbs/view2.php?S_Publ_Year=2015&word=&page=1&B_Code=277

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-09-09   Modified: 2017-05-10  

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