Mechanisms of chronic itch via astrocytic STAT3 in the spinal cord
| Project/Area Number |
26893182
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pain science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 痒み / 慢性的な痒み / アトピー性皮膚炎 / 脊髄 / アストロサイト / 痒み過敏 / 慢性掻痒 / グリア細胞 |
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| Outline of Final Research Achievements |
Using models of chronic itch such as atopic or contact dermatitis model mice, we identified LCN2 as an astrocytic STAT3-dependent upregulated factor that plays important roles in maintenance of chronic itch in the spinal dorsal horn. We also demonstrated that LCN2 participates in spinal itch sensitization through enhancement of itch-specific GRP-GRPR signaling in the dorsal horn.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch2015
Author(s)
Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M
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Journal Title
Nat Med
Volume: 21
Issue: 8
Pages: 927-931
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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