The effect and role of SOCS (suppressor of cytokine signaling) in the cancer vaccine therapy for biliary tract cancer.
| Project/Area Number |
26893183
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kyushu University |
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Principal Investigator |
OGATA HISANOBU 九州大学, 生体防御医学研究所, 助教 (70432945)
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| Research Collaborator |
TANI Kenzaburo 東京大学, 医科学研究所, 特任教授 (00183864)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
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| Keywords | 癌ワクチン / 胆道癌 / 免疫 / 免疫療法 / 癌 / シグナル伝達 / ペプチド癌ワクチン / 免疫制御 / 免疫学 / トランスレーショナルリサーチ |
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| Outline of Final Research Achievements |
The applicants have performed the cocktail peptide cancer vaccine therapy Phase II clinical trial for the patients with the advanced biliary tract cancer that are resistant to current therapy. One of the cocktail peptide, OCV-105 to use for this clinical study was identified as a gene frequently expressed in pancreatic cancer and cholangiocarcinoma tissues by the comprehensive genome information by the cDNA microarray, and is the HLA-A2402-restricted epitope peptide which can induce CTL. Other two, elpamotide and OCV-101 to use in this trial are HLA-A-restricted epitope peptides derived from VEGFR1, 2 and are a receptor of VEGF-A. The induction of CTL targeting this receptor might be expected to inhibit the growth and metastasis of cancer cell.
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| Academic Significance and Societal Importance of the Research Achievements |
癌ワクチン療法における免疫学的解析をおこなう予定である。癌ワクチン療法における免疫学的解析をおこなった研究は少なく、学術的意義や社会的意義の高いものになると思われる。
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Angiotensin II type I receptor blocker, Losartan, inhibits fibrosis in liver by suppressing TGF-beta1 production.2016
Author(s)
Hisanobu Ogata, Hideko Noguchi, Toshio Ohtsubo, Jiyuan Liao, Hiroshi Kohara, Kazunari Yamada, Mutsunori Murahashi, Yasuki Hijikata, Atsushi Suetsugu, Robert M Hoffman, Kenzaburo Tani
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Journal Title
Integr Mol Med
Volume: 3
Pages: 520-523
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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