The effect of epileptic discharges on cognitive function: a near-infrared spectroscopy analyses

• Project/Area Number: 26893189
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Kyushu University
• Principal Investigator: SANEFUJI MASAFUMI 九州大学, 学内共同利用施設等, 研究員 (50467940)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: てんかん / 発達障害 / 脳波 / 近赤外線スペクトロスコピー / てんかん発射 / 脳神経疾患

Outline of Final Research Achievements

The main purpose of this study was to elucidate how epileptic discharges physiologically affect cognitive function in developmental disorders such as autism spectrum disorder. We conducted simultaneous measurement of electrical activity with electroencephalography and blood concentration change with near-infrared spectroscopy. We found that epileptic discharges induced the increase of oxy-hemoglobin and reduction of deoxy-hemoglobin. This suggests that epileptic discharges influence the oxygen and energy metabolism in the cerebral cortex. We also found that the cerebral blood change patterns depended on the locations of the discharges. This study will serve as the basis for future research to further clarify the association of the epileptic discharges with cognitive function in developmental disorders.

Research Products

• [Journal Article] Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice. (2016)
  • Author(s): Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, Sanefuji M, Ishizaki Y, Torisu H, Nakabeppu Y, Suzuki A, Takada H, Hara T.
  • Journal Title: Sci Rep Volume: 未 Issue: 1 Pages: 22991-22991
  • DOI: 10.1038/srep22991
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Periodic Epileptiform Discharges in Children With Advanced Stages of Progressive Myoclonic Epilepsy. (2015)
  • Author(s): Isobe N, Sakai Y, Kira R, Sanefuji M, Ishizaki Y, Sakata A, Sasazuki M, Torio M, Akamine S, Torisu H, Hara T.
  • Journal Title: Clinical EEG and neuroscience Volume: Epub Issue: 4 Pages: 317-323
  • DOI: 10.1177/1550059415579767
  • Peer Reviewed
• [Journal Article] Altered strategy in short-term memory for pictures in children with attention-deficit/hyperactivity disorder: a near-infrared spectroscopy study. (2014)
  • Author(s): Sanefuji M, Yamashita H, Torisu H, Takada Y, Imanaga H, Matsunaga M, Ishizaki Y, Sakai Y, Yoshida K, Hara T.
  • Journal Title: Psychiatry Research: Neuroimaging Volume: 223 Issue: 1 Pages: 37-42
  • DOI: 10.1016/j.pscychresns.2014.04.012
  • Peer Reviewed
• [Presentation] 早産児infantile spasmsにおける治療反応性の特徴 (2015)
  • Author(s): 鳥尾倫子、實藤雅文、酒井康成、石崎義人、鳥巣浩幸、笹月桃子、高田英俊.
  • Organizer: 第49回日本てんかん学会学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2015-10-30
• [Presentation] ローランド発射が先行した若年性ミオクロニーてんかんの1例 (2015)
  • Author(s): 石崎義人、酒井康成、實藤雅文、鳥尾倫子、赤峰哲、高田英俊
  • Organizer: 第10回日本てんかん学会九州地方会
  • Place of Presentation: 大分
  • Year and Date: 2015-07-11
• [Presentation] Carnitine palmitoyltransferase II (CPT2)の熱不安定性遺伝子多型と熱性けいれん発症の関連について (2015)
  • Author(s): 石崎義人、酒井康成、實藤雅文、鳥尾倫子、原寿郎
  • Organizer: 第57回日本小児神経学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-05-28
• [Presentation] 当院におけるウエスト症候群50例の検討 (2015)
  • Author(s): 鳥尾倫子、酒井康成、實藤雅文、笹月桃子、石崎義人、鳥巣浩幸、原寿郎
  • Organizer: 第57回日本小児神経学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-05-28