Research Project
Grant-in-Aid for Research Activity Start-up
The main purpose of this study was to elucidate how epileptic discharges physiologically affect cognitive function in developmental disorders such as autism spectrum disorder. We conducted simultaneous measurement of electrical activity with electroencephalography and blood concentration change with near-infrared spectroscopy. We found that epileptic discharges induced the increase of oxy-hemoglobin and reduction of deoxy-hemoglobin. This suggests that epileptic discharges influence the oxygen and energy metabolism in the cerebral cortex. We also found that the cerebral blood change patterns depended on the locations of the discharges. This study will serve as the basis for future research to further clarify the association of the epileptic discharges with cognitive function in developmental disorders.
All 2016 2015 2014
All Journal Article (3 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 3 results, Open Access: 1 results) Presentation (4 results)
Sci Rep
Volume: 未 Issue: 1 Pages: 22991-22991
10.1038/srep22991
Clinical EEG and neuroscience
Volume: Epub Issue: 4 Pages: 317-323
10.1177/1550059415579767
Psychiatry Research: Neuroimaging
Volume: 223 Issue: 1 Pages: 37-42
10.1016/j.pscychresns.2014.04.012