The effect of epileptic discharges on cognitive function: a near-infrared spectroscopy analyses
Project/Area Number |
26893189
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Pediatrics
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Research Institution | Kyushu University |
Principal Investigator |
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Project Period (FY) |
2014-08-29 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | てんかん / 発達障害 / 脳波 / 近赤外線スペクトロスコピー / てんかん発射 / 脳神経疾患 |
Outline of Final Research Achievements |
The main purpose of this study was to elucidate how epileptic discharges physiologically affect cognitive function in developmental disorders such as autism spectrum disorder. We conducted simultaneous measurement of electrical activity with electroencephalography and blood concentration change with near-infrared spectroscopy. We found that epileptic discharges induced the increase of oxy-hemoglobin and reduction of deoxy-hemoglobin. This suggests that epileptic discharges influence the oxygen and energy metabolism in the cerebral cortex. We also found that the cerebral blood change patterns depended on the locations of the discharges. This study will serve as the basis for future research to further clarify the association of the epileptic discharges with cognitive function in developmental disorders.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice.2016
Author(s)
Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, Sanefuji M, Ishizaki Y, Torisu H, Nakabeppu Y, Suzuki A, Takada H, Hara T.
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Journal Title
Sci Rep
Volume: 未
Issue: 1
Pages: 22991-22991
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Periodic Epileptiform Discharges in Children With Advanced Stages of Progressive Myoclonic Epilepsy.2015
Author(s)
Isobe N, Sakai Y, Kira R, Sanefuji M, Ishizaki Y, Sakata A, Sasazuki M, Torio M, Akamine S, Torisu H, Hara T.
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Journal Title
Clinical EEG and neuroscience
Volume: Epub
Issue: 4
Pages: 317-323
DOI
Related Report
Peer Reviewed
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