The effect of farnesyltransferase inhibitor on acute liver dysfunction
| Project/Area Number |
26893193
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | farnesytransferase / farnesyltransferase / ファルネシル化 |
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| Outline of Final Research Achievements |
This study revealed that farnesyltransferase inhibitor have the effect of hepatoprotective action for local acute liver failure. Specifically, with a mouse acute liver failure model, the inflammation reaction in the liver attenuated by the farnesyltransferase inhibitor and improved a survival rate.
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Report
(3 results)
Research Products
(2 results)
