The effect of farnesyltransferase inhibitor on acute liver dysfunction

Research Project

Project/Area Number	26893193
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Anesthesiology
Research Institution	Kyushu University
Principal Investigator	Shirozu Kazuhiro 九州大学, 大学病院, 助教 (30568960)
Project Period (FY)	2014-08-29 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	farnesytransferase / farnesyltransferase / ファルネシル化
Outline of Final Research Achievements	This study revealed that farnesyltransferase inhibitor have the effect of hepatoprotective action for local acute liver failure. Specifically, with a mouse acute liver failure model, the inflammation reaction in the liver attenuated by the farnesyltransferase inhibitor and improved a survival rate.