| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Recently, it is reported that obesity or obesity-related development of diabetes are deeply involved in the increase of fracture risk, acceleration of bone resorption, and development of periodontal disease. Abnormal production of an adipokine, which is physiologically active substance secreted from adipose tissue, is a factor of these risk, however, the association of adipokines and osteoclasts specialized in bone resorption are poorly understood. We showed the possibility that RBP4, an adipokine which is a factor to induce diabetes, negatively regulates the osteoclast differentiation. Therefore, RBP4 could be a new target for the control of bone destruction.
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