CaMK4 inhitotion in rheumatoid arthritis for the immunological remission
Project/Area Number |
26893198
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Nagasaki University |
Principal Investigator |
KOGA Tomohiro 長崎大学, 病院(医学系), 助教 (90537284)
|
Project Period (FY) |
2014-08-29 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 関節リウマチ / CaMK4 / 関節炎誘導マウス |
Outline of Final Research Achievements |
We investigated the relationship between RA development and the expression of CaMK4 in CD4 T cell and found that the level of Camk4 mRNA was significantly higher in patients with RA. This data indicated the abnormal CaMK4 expression and function contributes to the pathogenesis of RA. We further examined the relationship between CaMK4 expression and disease activity among RA patients but there was no significant difference. To determine the protective effect on collagen induced arthritis in mice, we treated with the CaMK4 inhibitor. Importantly, the group treated with CaMK4 inhibitor exhibited the significant improvement of arthritis indicating the possible therapeutic target for RA.
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Report
(3 results)
Research Products
(3 results)
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[Presentation] Role of CaMK4 in the pathogenesis of rheumatoid arthritis2016
Author(s)
Tomohiro Koga,Masataka Umeda,Yasuko Hirai,Toru Michitsuji,Toshimasa Shimizu,Shoichi Fukui,Ayako Nishino,Yoshikazu Nakashima,Shin-ya Kawashiri,Naoki Iwamoto,Kunihiro Ichinose,Mami Tamai,Tomoki Origuchi,Hideki Nakamura,Atsushi Kawakami
Organizer
第60回日本リウマチ学会総会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-04-21 – 2016-04-21
Related Report
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