Identification of hepatic maturation mechanisms of human iPS cells by using chemical screening
| Project/Area Number |
26893201
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kumamoto University |
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Principal Investigator |
YAMAZOE Taiji 熊本大学, 発生医学研究所, 特定事業研究員 (20736219)
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| Research Collaborator |
KUME Shoen 熊本大学, 発生医学研究所, 教授 (70347011)
SHIRAKI Nobuaki 熊本大学, 発生医学研究所, 準教授 (70448520)
SASAKI Yutaka 熊本大学, 大学院生命科学研究部, 教授 (70235282)
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| Project Period (FY) |
2014-08-29 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | iPS細胞由来肝細胞 / 肝細胞成熟化 / ケミカルスクリーニング / 肝細胞分化誘導法 / iPS細胞 |
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| Outline of Final Research Achievements |
The chemical screening were carried out for the identification of candidate drug that potentiates hepatic maturation of human iPS derived cells. We obtained the candidate reagent that increases mature hepatocyte marker, Albumin positive cells and decreases immature hepatocyte marker, AFP positive cells. This candidate drug will give us the new aspects of hepatic maturation mechanisms, based on the knowledge of its molecular targets and their down stream molecules. This candidate drug is available in clinic, so that it might be possible to utilize this candidate drug for inducing a maturation of human iPS derived hepatocytes without toxic effects of drugs.
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Report
(2 results)
Research Products
(2 results)
