| Project/Area Number |
26893207
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脂肪細胞分化 |
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| Outline of Final Research Achievements |
Cockayne syndrome (CS) is a rare autosomal recessive disease with a mutation on DNA repair genes against the UV induced DNA lesions. Since CS has multiple phenotypes, not only the skin disease but also severe growth retardation, the pathophysiological symptoms of CS patients are rather complicated. To explore the new function of CS responding genes, we investigated the adipocytes cell-differentiation experiments using 3T3-L1 cells. Ercc6, one of CS syndrome genes, knockout cells by CRISPR-Cas9 system showed the alteration of cell differentiation to adipocyte upon the inducing factors.
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