Clarification of the role of Big angiotensin-25 in the tissue angiotensin II generation.
| Project/Area Number |
26893209
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
NAGATA SAYAKA 宮崎大学, 医学部, 研究員(特任助教) (00452920)
|
|---|
| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | ビッグアンジオテンシン-25 / レニン・アンジオテンシン系 / 生理活性ペプチド / バイオマーカー / 循環器疾患 / 腎臓疾患 |
|---|
| Outline of Final Research Achievements |
We developed an assay of big angiotensin-25 (Bang-25) and measured human urinary Bang-25. Negative correlation between the estimated glomerular filtration rate and urinary Bang-25 was found, but did not relate to the urine protein in patients with the kidney disease. When compared with diabetes mellitus patients, the urinary Bang-25 was significantly higher than healthy volunteer. These results suggest that urinary Bang-25 concentration may reflect the extent of kidney injury.
In addition, we found that plasma Angiotensinogen (Aogen) has three types of glycosyl chain at position 14th amino acid. One glycosyl chain structure is identical to Bang-25 in urine. The structure of the glycosyl chain at position 14th amino acid of the human Aogen may be involved in the substrate specificity for renin or chymase.
|
Report
(3 results)
Research Products
(17 results)
-
[Journal Article] Inhibitory effects of two G protein-coupled receptor kinases on the cell surface expression and signaling of the human adrenomedullin receptor.2016
Author(s)
Kuwasako, K., Sekiguchi, T., Nagata, S., Jiang, D., Hayashi, H., Murakami, M., Hattori, Y., Kitamura, K. and Kato, J.
-
Journal Title
Biochem. Biophys. Res. Commun.
Volume: 470
Issue: 4
Pages: 894-899
DOI
Related Report
Peer Reviewed
-
[Journal Article] Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue.2015
Author(s)
Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM
-
Journal Title
Ther Adv Cardiovasc Dis.
Volume: 9(4)
Issue: 4
Pages: 168-180
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
