| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We developed an assay of big angiotensin-25 (Bang-25) and measured human urinary Bang-25. Negative correlation between the estimated glomerular filtration rate and urinary Bang-25 was found, but did not relate to the urine protein in patients with the kidney disease. When compared with diabetes mellitus patients, the urinary Bang-25 was significantly higher than healthy volunteer. These results suggest that urinary Bang-25 concentration may reflect the extent of kidney injury.
In addition, we found that plasma Angiotensinogen (Aogen) has three types of glycosyl chain at position 14th amino acid. One glycosyl chain structure is identical to Bang-25 in urine. The structure of the glycosyl chain at position 14th amino acid of the human Aogen may be involved in the substrate specificity for renin or chymase.
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