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Molecular epidemiological analysis of Streptococcus pneumoniae for serotype distribution and drug resistance with the use of novel genetic methods

Research Project

Project/Area Number 26893212
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Hygiene and public health
Research InstitutionSapporo Medical University

Principal Investigator

Kawaguchiya Mitsuyo  札幌医科大学, 医学部, 助教 (70733062)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords肺炎球菌 / 分子疫学 / 血清型 / 薬剤耐性 / ワクチン / サーベイランス / 予防医学 / ペニシリン
Outline of Final Research Achievements

Changes in serotypes and its relationship to macrolide resistance genes were investigated for 2057 noninvasive isolates of S. pneumoniae during the PCV7- and PCV13-routine immunization periods and compare it with previous data of the PCV7 voluntary immunization period. In addition, susceptibility to antibiotics was tested for the isolates with non-PCV13 serotypes. As a result, PCV7 serotypes decreased among children, while the rates of non-PCV13 serotypes increased significantly, and serotypes 15A, 15C, and 23A mostly harbored erm(B). In the antimicrobial susceptibility testing, 42.0% of the non-PCV13 serotypes isolates showed multidrug resistance (MDR). All the serotype 15A isolates were MDR and non-susceptible to penicillin (PRSP or PISP), and all the PRSP-15A isolates were classified into ST63, indicating the emergence of the clone in Hokkaido.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (9 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (6 results) (of which Invited: 1 results)

  • [Journal Article] High prevalence of genotype 6E (putative serotype 6E) among noninvasive/colonization isolates of Streptococcus pneumoniae in northern Japan2015

    • Author(s)
      Kawaguchiya M, Urushibara N, Kobayashi N.
    • Journal Title

      Microbial Drug Resistance

      Volume: 21 Issue: 2 Pages: 209-214

    • DOI

      10.1089/mdr.2014.0181

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Emerging non-PCV13 serotypes of noninvasive Streptococcus pneumoniae with macrolide resistance genes in northern Japan.2015

    • Author(s)
      Kawaguchiya M, Urushibara N, Aung MS, Morimoto S, Ito M, Kudo K, Sumi A, Kobayashi N.
    • Journal Title

      New Microbes and New Infections

      Volume: 11 Pages: 66-72

    • DOI

      10.1016/j.nmni.2015.11.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serotype distribution and susceptibility to penicillin and erythromycin among noninvasive or colonization isolates of Streptococcus pneumoniae in northern Japan: a cross-sectional study in the pre-PCV7 routine immunization period2014

    • Author(s)
      Kawaguchiya M, Urushibara N, Ghosh S, Kuwahara O, Morimoto S, Ito M, Kudo K, Kobayashi N.
    • Journal Title

      Microbial Drug Resistance

      Volume: 20 Issue: 5 Pages: 456-465

    • DOI

      10.1089/mdr.2013.0196

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Temporal changes in serotypes and macrolide resistance genotypes of S. pneumoniae in Hokkaido2016

    • Author(s)
      川口谷充代、漆原範子、小林宣道
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 7価および13価肺炎球菌結合型ワクチン導入による非侵襲性肺炎球菌臨床分離株の血清型の変化2015

    • Author(s)
      川口谷充代
    • Organizer
      第2回北海道臨床微生物フォーラム
    • Place of Presentation
      札幌医科大学記念ホール (札幌)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 非侵襲性肺炎球菌の莢膜血清型とマクロライド耐性遺伝子型の推移2015

    • Author(s)
      川口谷充代、鷲見紋子、小林宣道
    • Organizer
      第74回日本公衆衛生学会総会
    • Place of Presentation
      長崎ブリックホール (長崎)
    • Year and Date
      2015-11-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] PCV7およびPCV13導入による非侵襲性肺炎球菌臨床分離株の血清型の変化2015

    • Author(s)
      川口谷充代、漆原範子、小林宣道
    • Organizer
      第89回日本感染症学会総会
    • Place of Presentation
      国立京都国際会館 (京都)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] PCV7導入における肺炎球菌の莢膜血清型とマクロライド耐性遺伝子型の変化傾向2015

    • Author(s)
      川口谷充代、漆原範子、Meiji Soe Aung、小林宣道
    • Organizer
      日本細菌学会
    • Place of Presentation
      長良川国際会議場 (岐阜県岐阜市)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 7価小児用肺炎球菌結合型ワクチン導入後における肺炎球菌血清型の分布状況2014

    • Author(s)
      川口谷充代、 鷲見紋子、 小林宣道
    • Organizer
      日本公衆衛生学会
    • Place of Presentation
      栃木県総合文化センター (栃木県宇都宮市)
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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