Molecular epidemiological analysis of Streptococcus pneumoniae for serotype distribution and drug resistance with the use of novel genetic methods
| Project/Area Number |
26893212
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene and public health
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 肺炎球菌 / 分子疫学 / 血清型 / 薬剤耐性 / ワクチン / サーベイランス / 予防医学 / ペニシリン |
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| Outline of Final Research Achievements |
Changes in serotypes and its relationship to macrolide resistance genes were investigated for 2057 noninvasive isolates of S. pneumoniae during the PCV7- and PCV13-routine immunization periods and compare it with previous data of the PCV7 voluntary immunization period. In addition, susceptibility to antibiotics was tested for the isolates with non-PCV13 serotypes. As a result, PCV7 serotypes decreased among children, while the rates of non-PCV13 serotypes increased significantly, and serotypes 15A, 15C, and 23A mostly harbored erm(B). In the antimicrobial susceptibility testing, 42.0% of the non-PCV13 serotypes isolates showed multidrug resistance (MDR). All the serotype 15A isolates were MDR and non-susceptible to penicillin (PRSP or PISP), and all the PRSP-15A isolates were classified into ST63, indicating the emergence of the clone in Hokkaido.
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Report
(3 results)
Research Products
(9 results)
