| Project/Area Number |
26893239
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
Matsusue Yumiko 奈良県立医科大学, 医学部附属病院, 研究員 (60571007)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 咀嚼 / 幼少期 / 脳発達 / 行動 / 軟食 / 硬食 / 神経新生 |
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| Outline of Final Research Achievements |
Several weeks after the weaning period is an extremely important time to acquire masticatory function, and sudden cranial nerve development occurs at the same time. In order to elucidate the influence of chewing after weaning on brain function and molecular basis affecting behavior, we fed soft-diet soft-diet (powder chow) or hard diet (solid chow) after weaning Using the mouse model, the influence of differences in diet shape on the plasticity of the brain during the developmental period and growth after childhood chewing function acquisition phase was analyzed from the molecular biology to the behavioral science step by step . Expression in the brain of each model mouse was observed using NG2, CAII which are markers of glial cells (oligodendrocytes), and it was observed that the hard food group tended to be strongly expressed. It was suggested that child rearing environment such as chewing in early childhood may cause plastic change in neural network at the growth stage.
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