Involvement of TRPA1 in oral cancer-induced mechanical pain
| Project/Area Number |
26893243
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
Ono Kentaro 九州歯科大学, 歯学部, 准教授 (40316154)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | TRPA1 / P2X3 / ATP / ガン性疼痛 / 接触痛 / P2X2 / Cancer pain / Mechanical allodynia |
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| Outline of Final Research Achievements |
Oral cancer induces pain during meals when food and teeth touch on cancer region. In previous studies, it has been reported that adenosine triphosphate released from cancer causes mechanical pain. However, it is unclear which mechano-sensitive channels are involved. In this study, we investigated whether the mechano-sensitive channel TRPA1 is related in cancer-induced mechanical pain. Consequently, we revealed that mechanical pain is mediated by sensitization of TRPA1 following activation of P2X3 in the response to adenosine triphosphate.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil.2016
Author(s)
Yamaguchi, K., Ono, K., Hitomi, S., Ito, M., Nodai, T., Goto, T., Harano, N., Watanabe, S., Inoue, H., Miyano, K., Uezono, Y., Matoba, M., Inenaga, K.
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Journal Title
Pain
Volume: 157
Issue: 5
Pages: 1004-1020
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Novel methods of applying direct chemical and mechanical stimulation to the oral mucosa for traditional behavioral pain assays in conscious rats.2015
Author(s)
Hitomi S, Ono K, Miyano K, Ota Y, Uezono Y, Matoba M, Kuramitsu S, Yamaguchi K, Matsuo K, Seta Y, Harano N, Inenaga K.
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Journal Title
J Neurosci Methods
Volume: 239
Pages: 162-169
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Analgesic effect of hangeshashinto on oral ulcer-induced pain in rats.2015
Author(s)
Hitomi, S., Ono, K., Yamaguchi, K., Omiya, Y., Terawaki, K. and Inenaga, K.
Organizer
The 92nd Annual Meeting of The Physiological Society of Japan
Place of Presentation
Kobe, Japan
Year and Date
2015-03-21 – 2015-03-23
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