Lipidomic profiling reveals biomarkers for prevention of alcohol intake and alcohol-induced diseases
| Project/Area Number |
26893258
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Keio University |
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Principal Investigator |
HARADA Sei 慶應義塾大学, 医学部, 助教 (10738090)
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| Project Period (FY) |
2014-08-29 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | メタボローム / 疫学 / 遺伝子多型 / 個別化医療 / アルコール / 予防医学 / リピドミクス / メタボロミクス疫学 / 地域コホート研究 / 個別化予防医療 / 飲酒性疾患 / ALDH2 |
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| Outline of Final Research Achievements |
Daily alcohol intake is a risk factor of various diseases. Prevention in the early stage of alcohol-induced diseases is necessary, however, few blood biomarkers of alcohol intake and alcohol-induced diseases are known.
In this study, we performed lipidomic profiling of 1008 plasma samples collected from residents in Tsuruoka City, identifying and quantifying 232 lipids. Lipidome were quite different by alcohol intake, and some biomarkers for prevention were found. Lipidome of heavy drinkers were also different by alcohol related genotype. This study suggests that lipidomic profiling is useful for personalized prevention of alcohol-induced diseases.
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Report
(2 results)
Research Products
(1 results)
