The expression and function of Heme Oxygenase in epidermal development and stress regulation

Research Project

Project/Area Number	26893260
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Dermatology
Research Institution	Keio University
Principal Investigator	Fujita Harumi 慶應義塾大学, 医学部, 特任助教 (30736971)
Project Period (FY)	2014-08-29 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	皮膚 / 酸化ストレス / 鉄 / 表皮 / ヘム / 炎症 / 角化
Outline of Final Research Achievements	Heme Oxygenases (HOs) are heme-catabolizing enzymes known as cytoprotective molecules against oxidative stresses. We analyzed the expression and function of HO in the epidermis. HO-1 is specifically expressed in the uppermost layer of stratum granulosum, however, epidermal-specific HO-1/2 double knockout mice had no phenotype in both physiological and stressed conditions, e.g. UV irradiation and wound healing. These results suggested the function of HOs in epidermal development and stress regulation are compensated by other unidentified proteins. Now we are investigating the function of HO in the iron recycling in the epidermis.