Induction of the lacrimal gland cells from stem cells by the regulation of transcriptional factors expression
| Project/Area Number |
26893262
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 涙腺再生 / 分化誘導 / 合成mRNA / ドライアイ / 涙腺 / 転写因子 / 幹細胞 / 再生医療 |
|---|
| Outline of Final Research Achievements |
The lacrimal glands play an important role to maintain a healthy ocular surface by secreting tear fluids. The regeneration of the lacrimal glands are expected as an next generation therapeutic strategy for the therapy of severe dry eye diseases. In this study, we have clarified the cell characteristics including cytokeratin expression and gene expression profile of the mice lacrimal gland germ epithelium, which have an ability of organogenesis of the lacrimalglands. It have shown that the expression of our identified genes are crucial for the development and differentiation of the lacrimal glands.
|
Report
(3 results)
Research Products
(5 results)
