| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The lacrimal glands play an important role to maintain a healthy ocular surface by secreting tear fluids. The regeneration of the lacrimal glands are expected as an next generation therapeutic strategy for the therapy of severe dry eye diseases. In this study, we have clarified the cell characteristics including cytokeratin expression and gene expression profile of the mice lacrimal gland germ epithelium, which have an ability of organogenesis of the lacrimalglands. It have shown that the expression of our identified genes are crucial for the development and differentiation of the lacrimal glands.
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