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Pathophysiological analysis of Parkinson disease and related disorders using Dopamine transporter imaging and MRI

Research Project

Project/Area Number 26893266
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionJuntendo University

Principal Investigator

KAMAGATA KOJI  順天堂大学, 医学部, 助教 (60568153)

Research Collaborator HORI Masaaki  順天堂大学, 医学部, 助教 (40334867)
YOSHIDA Mariko  順天堂大学, 医学部, 非常勤助手 (30755525)
Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsドパミントランスポーターイメージング / MRI / パーキンソン病 / 磁化率強調像 / NODDI / 拡散MRI / DAT-SPECT / ドパミントランスポーターイメージ
Outline of Final Research Achievements

We investigated whether 3T susceptibility weighted imaging (SWI) can be used to detect the presence or absence of nigrosome-1 in patients with a differential diagnosis of Parkinson`s disease (PD) and Dementia with Lewy bodies (DLB). We demonstrated that 3T SWI used to assess the presence or absence of nigrosome-1 had high diagnostic accuracy in a population of patients with a differential diagnosis of PD and DLB. Furthermore, we demonstrated that results obtained by using SWI to assess the presence or absence of nigrosome-1 are comparable to those obtained with DAT-SPECT using 123I-FP-CIT.
We investigated the relationship between diffusion MRI (NODDI, DTI) and specific binding ratio (SBR) as an indicator of dopamine transporter density. On correlation analysis, right SBR and right posterior putamen OD showed negative correlation. Changes in the posterior putamen on OD map suggested nigrostriatal dopaminergic nerve cell loss in PD.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (5 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] What is NODDI and what is its role in Parkinson's assessment?2016

    • Author(s)
      Kamagata K, Hatano T, Aoki S.
    • Journal Title

      Expert Rev Neurother

      Volume: 16 Issue: 3 Pages: 241-243

    • DOI

      10.1586/14737175.2016.1142876

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Anatomical Imaging: DTI and Cortical Thickness Imaging2016

    • Author(s)
      Koji Kamagata
    • Organizer
      The 15th international Parkinson`s disease symposium in Takamatsu
    • Place of Presentation
      Takamatsu
    • Year and Date
      2016-05-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] パーキンソン病における神経変性の評価:NODDI定量値とDAT-SPECTとの関連2016

    • Author(s)
      村田渉,鎌形康司,波田野琢,奥住文美,堀正明,鈴木通真,鶴田航平,服部信孝,青木茂樹,妹尾 淳史
    • Organizer
      第39回日本脳神経CI学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-01-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] NODDIを用いたパーキンソン病における基底核変性の評価:ドパミントランスポーターSPECTとの関連2015

    • Author(s)
      村田渉,鎌形康司,波田野琢,奥住文美,堀正明,鈴木通真,下地啓五,濱崎望,佐藤秀二,鶴田航平,中澤美咲,上田亮,服部信孝,青木茂樹,妹尾淳史
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 磁化率強調像によるLewy小体病におけるニグロソームの評価:ドパミントランスポーターSPECTとの比較.2015

    • Author(s)
      鎌形康司、榊原隆次、中塚智也、堀正明、鈴木通真、岸雅彦、露崎洋平、舘野冬樹、青木茂樹、寺田一志.
    • Organizer
      第44回日本神経放射線学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-06 – 2015-03-07
    • Related Report
      2014 Annual Research Report

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Published: 2014-09-09   Modified: 2017-10-19  

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