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Development and functional analysis of biomarkers and therapeutic targets of giant cell tumor of bone.

Research Project

Project/Area Number 26893267
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionJuntendo University

Principal Investigator

OKUBO TAKETO  順天堂大学, 医学部, 助教 (90732884)

Research Collaborator Suehara Yoshiyuki  順天堂大学, 医学部, 准教授 (70509405)
Saito Tsuyoshi  順天堂大学, 医学部, 准教授 (80439736)
Mukaihara Kenta  
Akaike Keisuke  
Tanabe Yu  
Ishii Midori  
Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords骨軟部腫瘍 / 骨巨細胞腫 / プロテオミクス
Outline of Final Research Achievements

To verify the prediction abitities of patient's outcomes in GCTBs, the protein expressions of the GPX family (especially GPX1 and GPX3) and the gene alteration of TP53 gene were analyzed using the large validation cohort. The results of validations showed that the expression of GPX family and gene mutation of TP53 had statistical significant difference of prognosis in GCTBs. In order to establish the protein profiles of GCTBs and elucidate the biological characteristics of GCTBs, comprehensive protein expression analyses were performed using frozen surgical specimen of GCTBs and the identified protein profiles were analyzed according to clinico-pathological features including patient's outcome and drug sensitivities. We found the characteristic proteins which were associated with denosumab treatments and sensitivities in GCTBs which is a therapeutic agent for GCTB.

Report

(3 results)
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (15 results)

All 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 9 results,  Acknowledgement Compliant: 6 results) Presentation (4 results)

  • [Int'l Joint Research] Memorial Sloan-kettering Cancer Center(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab.2016

    • Author(s)
      Mukaihara K, Suehara Y, Kohsaka S, Akaike K, Tanabe Y, Kubota D, Ishii M, Fujimura T, Kazuno S, Okubo T, Takagi T, Yao T, Kaneko K, Saito T.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 2 Pages: e0148401-e0148401

    • DOI

      10.1371/journal.pone.0148401

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] An Outpatient-based Survey on the Recognition of Locomotive Syndrome in Japan: The Results of three Years of Surveys.2016

    • Author(s)
      Tanabe Y, Suehara Y, Okubo T, Kim Y, Ishii M,Kawasaki T, Matsuoka K, Akaike K, Mukaihara K, Kubota D, Okubo N, Maruyama Y, Saito T, Kaneko K.
    • Journal Title

      British Journal of Medicine & Medical Research.

      Volume: 15(9) Issue: 9 Pages: 1-9

    • DOI

      10.9734/bjmmr/2016/26127

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors2016

    • Author(s)
      Ishii M, Akaike K, Suehara Y, Mukaihara K, Kubota K , Kohsaka S, Okubo T, Mitani K, Mogushi K, Takagi T, Kaneko K, Yao T, Saito T.
    • Journal Title

      Modern Pathology.

      Volume: 29 Issue: 11 Pages: 1424-1432

    • DOI

      10.1038/modpathol.2016.138

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A comparative study of 2 screening tools for locomotive syndrome (the “Loco-check” and the “GLFS-25”): An orthopedic outpatient-based survey.2016

    • Author(s)
      Kim Y, Suehara Y, Ishii M, Kawasaki T, Matsuoka K, Okubo T, Okubo N, Tanabe Y, Akaike K, Mukaihara K, Kubota D, Maruyama Y, Saito T, Kaneko K.
    • Journal Title

      British Journal of Medicine & Medical Research

      Volume: 17(5) Issue: 5 Pages: 1-13

    • DOI

      10.9734/bjmmr/2016/28194

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Skeletal metastasis of unknown primary origin at the initial visit: A retrospective analysis of 286 cases.2015

    • Author(s)
      Takagi T, Katagiri H, Kim Y, Suehara Y, Kubota D, Akaike K, Ishii M, Mukaihara K, Okubo T, Murata H, Takahashi M, Kaneko K, Saito T.
    • Journal Title

      PLoS ONE.

      Volume: 10 Issue: 6 Pages: e0129428-e0129428

    • DOI

      10.1371/journal.pone.0129428

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TERT promoter mutations are a rare event in gastrointestinal stromal tumors2015

    • Author(s)
      Akaike K, Toda-Ishii M, Suehara Y, Mukaihara K, Kubota D, Mitani K, Takagi T, Kaneko K, Yao T, Saito T.
    • Journal Title

      SpringerPlus

      Volume: 4 Issue: 1 Pages: 836-836

    • DOI

      10.1186/s40064-015-1606-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Recognition of Locomotive Syndrome in 2014: A Cross-sectional Study in the Orthopeadic Outpatients in Tokyo.2015

    • Author(s)
      Ishii M, Kim Y, Suehara Y, Kawasaki T, Matsuoka J, Akaike K, Mukaihara K, Kubota D, Okubo T, Saito T, Takagi T, Kaneko K.
    • Journal Title

      British Journal of Medicine & Medical Research

      Volume: 6(6) Issue: 6 Pages: 606-616

    • DOI

      10.9734/bjmmr/2015/14207

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bilateral non-osteochondroma-related proximal tibiofibular synostosis2014

    • Author(s)
      Wakayama T, Imanishi J, Yazawa Y, Okubo T, Kaneko K.
    • Journal Title

      Skeletal Radiol.

      Volume: 43 Issue: 12 Pages: 1737

    • DOI

      10.1007/s00256-014-1932-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Desmoplastic fibroma of the rib with cystic change: a case report and literature review.2014

    • Author(s)
      Okubo T, Saito T, Takagi T, Suehara Y, Kaneko K.
    • Journal Title

      Skeletal Radiol.

      Volume: 43 Pages: 703-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] IRTに基づくロコモティブシンドローム診断ツールの解析2015

    • Author(s)
      金栄智 末原義之 川崎隆之 石井翠 松岡淨 赤池慶祐 向井原健太 大久保武人 髙木辰哉 金子和夫
    • Organizer
      第88回日本整形外科学会学術総会
    • Place of Presentation
      神戸ポートピアホテル 神戸
    • Year and Date
      2015-05-21 – 2015-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 当科を初診した悪性リンパ腫の21例2015

    • Author(s)
      大久保武人 栗原大聖 矢澤康男
    • Organizer
      第55回関東整形災害外科学会
    • Place of Presentation
      ラフレさいたま 埼玉
    • Year and Date
      2015-03-27 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転移性軟部腫瘍を初発症状とした癌症例の検討2015

    • Author(s)
      栗原大聖 大久保武人 矢澤康男
    • Organizer
      第55回関東整形災害外科学会
    • Place of Presentation
      ラフレさいたま 埼玉
    • Year and Date
      2015-03-27 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Solitary fibrous tumorにおけるNAB2-STAT6融合遺伝子のタイプと臨床病理像の検討2014

    • Author(s)
      赤池慶祐 末原義之 栗崎愛子 原貴恵子 大久保武人 鳥越知明 八尾隆史 金子和夫 髙木辰哉 齋藤剛
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      城山観光ホテル 鹿児島
    • Year and Date
      2014-10-09 – 2014-10-10
    • Related Report
      2014 Annual Research Report

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Published: 2014-09-09   Modified: 2018-03-22  

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