Development and functional analysis of biomarkers and therapeutic targets of giant cell tumor of bone.
| Project/Area Number |
26893267
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
OKUBO TAKETO 順天堂大学, 医学部, 助教 (90732884)
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| Research Collaborator |
Suehara Yoshiyuki 順天堂大学, 医学部, 准教授 (70509405)
Saito Tsuyoshi 順天堂大学, 医学部, 准教授 (80439736)
Mukaihara Kenta
Akaike Keisuke
Tanabe Yu
Ishii Midori
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 骨軟部腫瘍 / 骨巨細胞腫 / プロテオミクス |
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| Outline of Final Research Achievements |
To verify the prediction abitities of patient's outcomes in GCTBs, the protein expressions of the GPX family (especially GPX1 and GPX3) and the gene alteration of TP53 gene were analyzed using the large validation cohort. The results of validations showed that the expression of GPX family and gene mutation of TP53 had statistical significant difference of prognosis in GCTBs. In order to establish the protein profiles of GCTBs and elucidate the biological characteristics of GCTBs, comprehensive protein expression analyses were performed using frozen surgical specimen of GCTBs and the identified protein profiles were analyzed according to clinico-pathological features including patient's outcome and drug sensitivities. We found the characteristic proteins which were associated with denosumab treatments and sensitivities in GCTBs which is a therapeutic agent for GCTB.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab.2016
Author(s)
Mukaihara K, Suehara Y, Kohsaka S, Akaike K, Tanabe Y, Kubota D, Ishii M, Fujimura T, Kazuno S, Okubo T, Takagi T, Yao T, Kaneko K, Saito T.
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Journal Title
PLoS One
Volume: 10
Issue: 2
Pages: e0148401-e0148401
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] An Outpatient-based Survey on the Recognition of Locomotive Syndrome in Japan: The Results of three Years of Surveys.2016
Author(s)
Tanabe Y, Suehara Y, Okubo T, Kim Y, Ishii M,Kawasaki T, Matsuoka K, Akaike K, Mukaihara K, Kubota D, Okubo N, Maruyama Y, Saito T, Kaneko K.
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Journal Title
British Journal of Medicine & Medical Research.
Volume: 15(9)
Issue: 9
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors2016
Author(s)
Ishii M, Akaike K, Suehara Y, Mukaihara K, Kubota K , Kohsaka S, Okubo T, Mitani K, Mogushi K, Takagi T, Kaneko K, Yao T, Saito T.
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Journal Title
Modern Pathology.
Volume: 29
Issue: 11
Pages: 1424-1432
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A comparative study of 2 screening tools for locomotive syndrome (the “Loco-check” and the “GLFS-25”): An orthopedic outpatient-based survey.2016
Author(s)
Kim Y, Suehara Y, Ishii M, Kawasaki T, Matsuoka K, Okubo T, Okubo N, Tanabe Y, Akaike K, Mukaihara K, Kubota D, Maruyama Y, Saito T, Kaneko K.
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Journal Title
British Journal of Medicine & Medical Research
Volume: 17(5)
Issue: 5
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Skeletal metastasis of unknown primary origin at the initial visit: A retrospective analysis of 286 cases.2015
Author(s)
Takagi T, Katagiri H, Kim Y, Suehara Y, Kubota D, Akaike K, Ishii M, Mukaihara K, Okubo T, Murata H, Takahashi M, Kaneko K, Saito T.
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Journal Title
PLoS ONE.
Volume: 10
Issue: 6
Pages: e0129428-e0129428
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The Recognition of Locomotive Syndrome in 2014: A Cross-sectional Study in the Orthopeadic Outpatients in Tokyo.2015
Author(s)
Ishii M, Kim Y, Suehara Y, Kawasaki T, Matsuoka J, Akaike K, Mukaihara K, Kubota D, Okubo T, Saito T, Takagi T, Kaneko K.
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Journal Title
British Journal of Medicine & Medical Research
Volume: 6(6)
Issue: 6
Pages: 606-616
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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