Dark/light transition and vigilance states modulate jaw-closing muscle activity level in mice.

• Project/Area Number: 26893270
• Research Category: Grant-in-Aid for Research Activity start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Showa University
• Principal Investigator: katayama keisuke 昭和大学, 歯学部, 助教 (10736664)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 睡眠時ブラキシズム / 生理学

Outline of Final Research Achievements

The selective serotonin reuptake inhibitor (SSRI) antidepressants have been suggested to be one of the exacerbating factors of bruxism. However, it is unknown whether SSRIs affect masseter muscle activity. In this study, we investigated the effects of chronic administration of the SSRI citalopram, on the masseter muscle activity during wakefulness, NREM sleep and REM sleep.Saline or citalopram were administered for 6 days using a subcutaneous osmotic minipump. Citalopram did not change the temporal pattern of sleep/wake distributions; however, Cit100 increased the duration of REM sleep episodes compared to saline. Citalopram did not affect the mean masseter EMG activity. However, Cit100 significantly increased the time engaged in the activation of masseter muscle in NREM sleep during the dark (02–08 h) and the light periods (08–14 h) compared to saline. These results suggest that higher dose of citalopram may weakly increase the masseter muscle activity during NREM sleep.

Research Products

• [Journal Article] Functional redundancy of protein kinase D1 and protein kinase D2 in neuronal polarity. (2015)
  • Author(s): Yamada M, Romero-Pita MC, Iijima T, Tsutsui KI
  • Journal Title: Neuroscience research Volume: 67 Pages: 129-141
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] シタロプラムはノンレム睡眠時の咬筋活動を変調させる (2016)
  • Author(s): 望月文子、井川泰葉、加藤隆史、片山慶祐、中村史朗、中山希世美、馬場一美、井上富雄
  • Organizer: 日本顎口腔機能学会 第56回学術大会
  • Place of Presentation: 埼玉
  • Year and Date: 2016-04-23
• [Presentation] マウス咬筋および頸筋の筋活動に対するシタロプラムの影響 (2015)
  • Author(s): 野川泰葉、望月文子、片山慶祐、加藤隆史、安部友佳、中村史朗、中山希世美、馬場一美、若林則幸、井上富雄
  • Organizer: 第57回歯科基礎医学会
  • Place of Presentation: 新潟
  • Year and Date: 2015-09-12
• [Presentation] シタロプラムがマウス咬筋および頸筋筋活動に及ぼす影響 (2015)
  • Author(s): 野川泰葉、望月文子、片山慶祐、安部友佳、加藤隆史、馬場一美、若林則幸、井上富雄
  • Organizer: 日本補綴歯科学会124回学術大会
  • Place of Presentation: 大宮
  • Year and Date: 2015-05-31
• [Presentation] マウス咬筋活動に対する睡眠―覚醒の影響 (2015)
  • Author(s): 片山慶祐, 望月文子, 加藤隆史, 池田美菜子,野川泰葉, 中村史朗,中山希世美, 馬場一美, 井上富雄
  • Organizer: 昭和大学歯学部文部科学省私立大学戦略的研究基盤形成支援事業平成26年度シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2015-03-28
• [Presentation] Modulation of masseter activity by vigilance states and circadian rhythm (2015)
  • Author(s): Mochizuki A, Katayama K, Kato T, Ikeda M, Nogawa Y, Nakamura S, Nakayama K, Kiyomoto M, Wakabayashi N, Baba K, Inoue T
  • Organizer: 第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-23
• [Presentation] マウス咬筋および頸筋筋活動に対するシタロプラムの影響 (2014)
  • Author(s): 野川泰葉, 望月文子, 片山慶祐, 池田美菜子, 安部友佳, 中村史朗, 中山希世美, 清本聖文, 加藤隆史, 馬場一美, 若林則幸, 井上富雄
  • Organizer: 第8回三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 軽井沢
  • Year and Date: 2014-10-18
• [Presentation] マウスにおける咬筋の筋活動に対する明暗および睡眠-覚醒サイクルの影響 (2014)
  • Author(s): 片山慶祐, 望月文子, 加藤隆史, 池田美菜子,野川泰葉, 中村史朗, 中山希世美, 若林則幸, 馬場一美, 井上富雄
  • Organizer: 日本顎口腔機能学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-04