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Dark/light transition and vigilance states modulate jaw-closing muscle activity level in mice.

Research Project

Project/Area Number 26893270
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Prosthodontics/ Dental materials science and
Research InstitutionShowa University

Principal Investigator

katayama keisuke  昭和大学, 歯学部, 助教 (10736664)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords睡眠時ブラキシズム / 生理学
Outline of Final Research Achievements

The selective serotonin reuptake inhibitor (SSRI) antidepressants have been suggested to be one of the exacerbating factors of bruxism. However, it is unknown whether SSRIs affect masseter muscle activity. In this study, we investigated the effects of chronic administration of the SSRI citalopram, on the masseter muscle activity during wakefulness, NREM sleep and REM sleep.Saline or citalopram were administered for 6 days using a subcutaneous osmotic minipump. Citalopram did not change the temporal pattern of sleep/wake distributions; however, Cit100 increased the duration of REM sleep episodes compared to saline. Citalopram did not affect the mean masseter EMG activity. However, Cit100 significantly increased the time engaged in the activation of masseter muscle in NREM sleep during the dark (02–08 h) and the light periods (08–14 h) compared to saline. These results suggest that higher dose of citalopram may weakly increase the masseter muscle activity during NREM sleep.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (8 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results)

  • [Journal Article] Dark/light transition and vigilance states modulate jaw-closing muscle activity level in mice.2015

    • Author(s)
      Katayama K, Mochizuki A, Kato T, Ikeda M, Ikawa Y, Nakamura S, Nakayama K, Wakabayashi N, Baba K, Inoue T.
    • Journal Title

      neuroscience research

      Volume: 101 Pages: 24-31

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] シタロプラムはノンレム睡眠時の咬筋活動を変調させる2016

    • Author(s)
      望月文子、井川泰葉、加藤隆史、片山慶祐、中村史朗、中山希世美、馬場一美、井上富雄
    • Organizer
      日本顎口腔機能学会 第56回学術大会
    • Place of Presentation
      埼玉
    • Year and Date
      2016-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス咬筋および頸筋の筋活動に対するシタロプラムの影響2015

    • Author(s)
      野川泰葉、望月文子、片山慶祐、加藤隆史、安部友佳、中村史朗、中山希世美、馬場一美、若林則幸、井上富雄
    • Organizer
      第57回歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] シタロプラムがマウス咬筋および頸筋筋活動に及ぼす影響2015

    • Author(s)
      野川泰葉、望月文子、片山慶祐、安部友佳、加藤隆史、馬場一美、若林則幸、井上富雄
    • Organizer
      日本補綴歯科学会124回学術大会
    • Place of Presentation
      大宮
    • Year and Date
      2015-05-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス咬筋活動に対する睡眠―覚醒の影響2015

    • Author(s)
      片山慶祐, 望月文子, 加藤隆史, 池田美菜子,野川泰葉, 中村史朗,中山希世美, 馬場一美, 井上富雄
    • Organizer
      昭和大学歯学部文部科学省私立大学戦略的研究基盤形成支援事業平成26年度シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Modulation of masseter activity by vigilance states and circadian rhythm2015

    • Author(s)
      Mochizuki A, Katayama K, Kato T, Ikeda M, Nogawa Y, Nakamura S, Nakayama K, Kiyomoto M, Wakabayashi N, Baba K, Inoue T
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス咬筋および頸筋筋活動に対するシタロプラムの影響2014

    • Author(s)
      野川泰葉, 望月文子, 片山慶祐, 池田美菜子, 安部友佳, 中村史朗, 中山希世美, 清本聖文, 加藤隆史, 馬場一美, 若林則幸, 井上富雄
    • Organizer
      第8回三叉神経領域の感覚-運動統合機構研究会
    • Place of Presentation
      軽井沢
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウスにおける咬筋の筋活動に対する明暗および睡眠-覚醒サイクルの影響2014

    • Author(s)
      片山慶祐, 望月文子, 加藤隆史, 池田美菜子,野川泰葉, 中村史朗, 中山希世美, 若林則幸, 馬場一美, 井上富雄
    • Organizer
      日本顎口腔機能学会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-04
    • Related Report
      2014 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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