Analysis of the role of small G protein Cdc42 during bone and cartilage development.

Research Project

Project/Area Number	26893271
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Prosthodontics/ Dental materials science and
Research Institution	Showa University
Principal Investigator	Suzuki Wataru 昭和大学, 歯学部, 助教 (10736680)
Project Period (FY)	2014-08-29 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	Cdc42 / 軟骨形成 / 軟骨 / 軟骨代謝
Outline of Final Research Achievements	The aim of this study, by clarify the function of small G protein Cdc42 in bone and cartilage formation, to explore the possibility of probable cause and its prevention and treatment method of congenital diseases, such as bone cartilage hypoplasia. We revealed that Cdc42 regulate proliferation and development of chondrocyte in growth plate of femur using by Cdc42 conditional knock out mice. Furthermore, lack of Cdc42 in cartilage caused low bone mineralization in trabecular bone.

Report

(3 results)