Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
Multiple urate transporters in the kidney are involved in the regulation of serum urate levels. In this study, we revealed that urate transporters are expressed in choroid plexus epithelial cells, ventricular ependymal cells which separates the ventricles and the parenchyma, and brain capillaries. By measuring the urate level in the cerebrospinal fluid (CSF), we revealed that urate in the CSF may be transported from the ventricle into the brain parenchyma by URAT1.
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