| Project/Area Number |
26893287
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
NAKAI Kumiko 日本大学, 歯学部, 助教 (50736725)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 脂肪細胞 / 歯周病 / CRP / 脂肪組織 / ECMP / IL-6 / TNF-α |
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| Outline of Final Research Achievements |
Elevated blood levels of C-reactive protein (CRP) have been reported in patients with severe periodontitis. Epidemiological studies have indicated the association between periodontitis and metabolic syndrome, which arises from visceral fat-type obesity. In this study, we focused on turnover of extracellular matrix (ECM) protein in adipose tissue and examined the effects of CRP on the expression of matrix metalloproteinases (MMPs) and its inhibitors (TIMPs). CRP increased the expression of MMP-1，-2，-3，-9，-11，-13，-14 and TIMP-1, but not TIMP-2. These results suggest that CRP inclines ECM turnover to the resolution, which may be involved in spread of adipose tissue area, via upregulation of multiple MMPs in adipocyte.
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