| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The purpose of the present study is to evaluate the mechanisms underlying tongue-referred pain associate-ed with tooth pulp inflammation through TLR4 signaling in trigeminal ganglion cells.
These results are the first documentation that TLR4 is involved in the ectopic tongue pain associated with M1TP inflammation. Following M1TP inflammation, Hsp70 is expressed in the pulpal tissues, transported to the cell bodies of the trigeminal ganglion neurons, or Hsp70 is expressed in TG cells, and then released from TG neurons innervating the inflamed M1TP. Hsp70 binds to TLR4 in TG neurons innervating the tongue, and the excitability of TG neurons innervating the tongue may be enhanced, resulting in ectopic tongue pain.
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