| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
This study aimed to establish an animal model of lymphedema, in order to examine its mechanisms, as well as effective methods to reduce or completely cure it. In mice, the lymph flows from the hind limb to the heart through the inguinal lymph node, abdominal and thoracic lymphatic vessels, and axillary lymph node, in this order. After inguinal lymphadenectomy, hind-limb lymphedema occurs, and persists for approximately 3 days. The study did not succeed in establishing a model of lymphedema, possibly due to the following: the mouse hind-limb lymphatic system under the skin is extensive, and the lymph flows through the abdominal and thoracic lymphatic vessels toward the axillary lymph node, consequently preventing hind-limb lymphedema from persisting long after inguinal lymphadenectomy.
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