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Analyse the effects of antimicrobe peptide Cathelicidin on dental pulp repair.

Research Project

Project/Area Number 26893301
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

Horibe Kanji  松本歯科大学, 歯学部, 助教 (70733509)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords歯学 / 細胞・組織 / 生体分子 / 免疫学 / 歯科 / 自然免疫 / 組織学
Outline of Final Research Achievements

Cathelicidin is an antimicrobial peptide, binding to FPR2, and initiates various physiological actions. We examined the temporal localization of Cathelicidin and Fpr2 in rat tooth germ differentiation. In later bell stage, Cathelicidin was seen in odontoblasts and Fpr2-positive cells localized under odontoblasts. After tooth crown formation, Cathelicidin positive signals disappeared in crown odontoblasts, whereas Fpr2 positive signals were kept in subodontoblastic layer. Next we observed localization of Cathelicidin and Fpr2 in repair model of dental pulp tissues after cavity preparation. At 3 days after, Cathelicidin positive inflammatory cells were seen in the pulp under dental cavity. At 7 days, Cathelicidin and Fpr2 positive signals were detected in odontoblast contacting reparative dentin and cells under cavity.
These results suggest that Cathelicidin-FPR2 signal is involved in physiologic and reparative dentin formation.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (3 results)

All 2015 2014

All Presentation (3 results)

  • [Presentation] 抗微生物ペプチドcathelicidinの象牙質修復に対する促進的関与2015

    • Author(s)
      堀部寛治,細矢明宏,平賀 徹,中村浩彰
    • Organizer
      第57回 歯科基礎医学会学術大会
    • Place of Presentation
      〒950-0078 新潟県新潟市中央区万代島6-1 朱鷺メッセ 新潟コンベンションセンター
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗微生物ペプチドcathelicidinの象牙質修復に対する促進的関与2015

    • Author(s)
      堀部寛治,細矢明宏,平賀 徹,中村浩彰
    • Organizer
      第33回 日本骨代謝学会学術集会
    • Place of Presentation
      〒160-8330 東京都新宿区西新宿2-2-1 京王プラザホテル
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラット歯・歯周組織におけるformyl peptide receptor 2(Fpr2)の局在2014

    • Author(s)
      堀部寛治、細矢明宏、平賀徹、中村浩彰
    • Organizer
      第56回 歯科基礎医学会学術大会
    • Place of Presentation
      福岡国際会議場(〒812-0032 福岡県福岡市博多区石城町2-1)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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