| Project/Area Number |
26893304
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Okayama University (2015)
Aichi Gakuin University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔常在菌 / 加齢 / 歯槽骨吸収 / 免疫応答 / 歯周組織 / 宿主 / periodontitis / host response |
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| Outline of Final Research Achievements |
Commensal flora has an influence on tissue homeostasis. In this study, we investigated the contribution of oral commensal flora on age-related alveolar bone loss in mice. Germ-free (GF) and conventionally reared (SPF) mice at 8 and 22 weeks old were used. The SPF mice but not GF mice showed age-related increase in alveolar bone loss, and there was a significant difference in alveolar bone loss between the two groups at 22 weeks old. The SPF mice exhibited the age-related increases in osteoclasts and CD4, CD68 positive cells around the alveolar bone surface, compared to the GF mice. In addition, gene and protein expression of interleukin (IL)-17A and chemokine ligand (CCL) 5 in gingival tissues were higher at 22 weeks compared 8 weeks in SPF mice. Oral commensal flora accelerates age-related alveolar bone loss in mice. IL-17A and CCL5 released by T cells, may play an important role in commensal flora-induced bone loss during the aging.
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