Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with and without growth
| Project/Area Number |
26893310
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory surgery
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | すりガラス様陰影 / ground glass nodule / ground glass opacity / 肺癌 / EGFR / CT / GGN / スリガラス陰影 / 癌遺伝子 / 腺癌 |
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| Outline of Final Research Achievements |
Pulmonary ground-glass nodules (GGNs) include both malignant and benign lesions. Some GGNs become larger, whereas others remain unchanged for years. We have previously reported that smoking history and large diameters are predictors for growth. However, the genetic differences among GGNs remain unclear.
In this study we comprehensively investigate the genetic features of 104 GGNs in terms of targetable or potentially targetable driver mutations including EGFR, KRAS, ALK, and HER2. “Incidence of 2-mm growth” and “Time to 2-mm growth” were analyzed according to the mutational status. Three-fourths of resected GGNs were positive for EGFR, KRAS, ALK, or HER2 mutations. Quadruple-negative tumors were associated with GGNs with no growth, whereas EGFR mutation-positive tumors were correlated with growth. These results provide insight into the genetic features of GGNs and help establish reasonable follow-up algorithms to reduce radiation exposure and avoid unnecessary surgeries.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] EGFR exon 18 mutations in lung cancer: molecular predictors of augmented sensitivity to afatinib or neratinib as compared with first or third generation TKIs.2015
Author(s)
Kobayashi Y, Togashi Y, Yatabe Y, Mizuuchi H, Park J, Kondo C, Shimoji M, Sato K, Suda K, Tomizawa K, Takemoto T, Hida T, Nishio K, and Mitsudomi T
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Journal Title
Clinical Cancer Research
Volume: 21
Issue: 23
Pages: 5305-5313
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] EGFR exon 18 mutations in lung cancer: molecular predictors of sensitivity to afatinib or neratinib but not to other EGFR-TKIs2015
Author(s)
Kobayashi Y, Togashi Y, Yatabe Y, Mizuuchi H, Park J, Kondo C, Shimoji M, Sato K, Suda K, Tomizawa K, Takemoto T, Hida T, Nishio K, and Mitsudomi T
Organizer
16th World Conference on Lung Cancer
Place of Presentation
アメリカ合衆国、デンバー
Year and Date
2015-09-06
Related Report
Int'l Joint Research
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